Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty

Phase 4 Unknown 100 enrolled DeClaire LaMacchia Orthopaedic Institute

RandomizedParallel-groupDouble-blindTreatment

Summary

Does the use of periarticular Exparel in total knee arthroplasty prove to more effectively manage post operative pain control than another local analgesic, Ropivacaine, when both are used as part of a multimodal pain management approach? The investigators hypothesize that Exparel, a bupivacaine liposomal injectable suspension, will improve total knee arthroplasty postoperative pain with significant improvement of early function outcomes.

Timeline

Start: 2014-05
Primary completion: 2015-03
Completion: 2016-06

Publications

DeClaire JH, Aiello PM, Warritay OK, Freeman DC. Effectiveness of Bupivacaine Liposome Injectable Suspension for Postoperative Pain Control in Total Knee Arthroplasty: A Prospective, Randomized, Double Blind, Controlled Study. J Arthroplasty. 2017 Sep;32(9S):S268-S271. doi: 10.1016/j.arth.2017.03.062. Epub 2017 Apr 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupivacaine	Other / unclassified	20 ml	Other
Comparator	Ropivacaine	Other / unclassified	—	Other
Background	Epinephrine	Other / unclassified	—	Other
Background	Ketorolac	Other / unclassified	—	Other
Background	Morphine	Other / unclassified	—	Other

Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty

Summary

Timeline

Publications

Drugs

Indications