The Effect of Anesthesia on Perioperative Muscle Weakness and Neuro-endocrine Stress Response

Summary

The effect of surgery, in contrary to critical illness, on muscle weakness hasn't been thoroughly investigated. Recent data suggest that elective surgery may also induce muscle weakness. The neuro-endocrine stress response could be involved in the pathophysiology. Whether the mode of anesthesia/analgesia can influence muscle weakness, by influencing the neuro-endocrine stress response is unknown. Gaining insight in this matter could affect quality of care and benefit patient recovery and satisfaction.

Timeline

Start

2018-09-01

Primary completion

2019-12-18

Completion

2019-12-30

Publications

• Van Boxstael S, Peene L, Dylst D, Penders J, Hadzic A, Meex I, Corten K, Mesotten D, Thiessen S. The effect of spinal versus general anaesthesia on perioperative muscle weakness in patients having bilateral total hip arthroplasty: a single center randomized clinical trial. Eur J Med Res. 2023 Oct 20;28(1):450. doi: 10.1186/s40001-023-01435-6.

Drugs

Indications