The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery

Phase 4 Unknown 50 enrolled Consultants in Ophthalmic and Facial Plastics Surgery

RandomizedSingle-groupTriple-blindTreatment

Summary

Tranexamic acid (TXA) is a synthetic inhibitor of plasminogen lysine receptor that has used to reduce intra-operative bleeding in a number of clinical scenarios. Anecdotally, TXA has used by plastic surgeons to reduce post-operative bruising. To date, there is limited data to valid the benefits and to evaluate the side effects of TXA. The objective of this study is to evaluate the effect of local TXA on edema and ecchymosis in eyelid surgery.

Timeline

Start: 2021-08-01
Primary completion: 2021-12-31
Completion: 2022-07-01

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tranexamic Acid	Small molecule	0.5 ml	Other
Subject	Tranexamic Acid	Small molecule	100 mg/ml	Other
Background	Bupivacaine	Other / unclassified	0.5 %	—
Background	Bupivacaine	Other / unclassified	2.25 ml	—
Background	Bupivacaine	Other / unclassified	2.5 ml	—
Background	Epinephrine	Other / unclassified	—	—
Background	Lidocaine	Other / unclassified	2 %	—
Background	Lidocaine	Other / unclassified	2.25 ml	—
Background	Lidocaine	Other / unclassified	2.5 ml	—

The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery

Summary

Timeline

Publications

Drugs

Indications