drugset / Trial / NCT05637853

Telemonitored Fast Track Medical Sequencing for Heart Failure With Reduced Ejection Fraction

NCT05637853

Phase 4 Active not recruiting 60 enrolled Göteborg University
NaSingle-groupOpen-labelTreatment

Summary

Research hypothesis: Fast telemonitored medical sequencing in patients with heart failure with reduced ejection fraction (HFrEF) is safe and feasible. Background: Modern therapy for HFrEF offers a highly effective arsenal of drugs, devices and interventional therapies, yet mortality and morbidity remain high in the cohort. One major problem is that drug therapy introduction and up titration has been very hard to implement in a majority of HFrEF patients. Most previous telemonitoring studies have focused on the continuous monitoring of patients and the monitoring itself has been the main intervention. A potentially more effective way to use telemonitoring in heart failure patients may be to combine the technique with a medical intervention when the patients are most vulnerable to heart failure events. The best therapeutic window lies in the period after newly diagnosed heart failure or right after a recent hospitalization following worsened chronic HFrEF. Method: We aim to use telemonitoring for fast sequencing of heart failure drugs for patients with HFrEF.

Timeline

Start
2022-10-22
Primary completion
2024-08-26
Completion
2026-08-26

Drugs

EvaluationDrugModalityDoseRoute
Subject Bisoprolol Other / unclassified
Subject Candesartan Unknown
Subject Carvedilol Other / unclassified
Subject Dapagliflozin Small molecule
Subject Empagliflozin Small molecule
Subject Enalapril Other / unclassified
Subject Eplerenone Unknown
Subject Losartan Other / unclassified
Subject Metoprolol Other / unclassified
Subject Ramipril Small molecule
Subject Sacubitril/Valsartan Unknown
Subject Spironolactone Small molecule
Subject Valsartan Small molecule