Opioid Sparing Anesthesia Care for Pediatric Patients Having Tonsil Surgery
Summary
This is a prospective, randomized, controlled, non-inferiority study of patients undergoing tonsil surgeries at Boston Children's Hospital Waltham. The overall aim is to evaluate the efficacy of an opioid anesthetic plan (morphine, ketorolac, and acetaminophen versus an opioid sparing anesthetic plan (dexmedetomidine, ketorolac and acetaminophen) for perioperative analgesia and recovery time in patients undergoing tonsillectomies and tonsillotomies at Boston Children's Hospital Waltham. Secondary measures include rescue opioids administered in post-anesthesia care unit (PACU), re-operation secondary to bleeding, emergence delirium, post-operative nausea and vomiting, intraoperative hemodynamics, intraoperative vasopressor administration, and length of procedure.
Timeline
- Start
- 2024-05-09
- Primary completion
- 2026-01-30
- Completion
- 2026-03-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dexmedetomidine | Other / unclassified | 1 ug/kg | Intravenous |
| Comparator | Morphine | Other / unclassified | 0.1 mg/kg | Intravenous |
| Background | Acetaminophen | Small molecule | 12.5 mg/kg | Intravenous |
| Background | Ketorolac | Other / unclassified | 0.5 mg/kg | Intravenous |