Drugs / Selenium
last change Nov 2025 re-read 2 minutes ago

Selenium

Other / unclassified

Developed for
prostate cancer · COVID-19 · infectious disease with sepsis · male infertility · urinary bladder cancer · acute kidney injury · cardiovascular disorder · cataract
+20 more · central serous chorioretinopathy · Chagas disease · chemotherapy-induced oral mucositis · colorectal adenoma · colorectal cancer · lichen planus, oral · lung cancer · lymphatic malformation · macular degeneration · multiple sclerosis · peripartum cardiomyopathy · precancerous condition · preneoplastic lesion · subarachnoid hemorrhage · trisomy 21 · tuberculosis · adenomatous colon polyp · end stage renal failure · endocrine exophthalmos · endometriosis
Investigated by
National Cancer Institute (NCI) · SWOG Cancer Research Network · Cancer and Leukemia Group B · NCIC Clinical Trials Group · Tehran University of Medical Sciences · University Health Network, Toronto
+60 more · Al-Azhar University · Alcon Research · Arkansas Children's Hospital Research Institute · Augusta University · Beijing Chao Yang Hospital · Beytepe Murat Erdi Eker State Hospital · CHRISTUS Health · Canadian Institutes of Health Research (CIHR) · Cefak KG, Kempten · Centre Hospitalier Universitaire Vaudois · Centre Hospitalier de Meaux · Children's Hospital Los Angeles · Children's Hospital of Michigan · Children's National Research Institute · Conselho Nacional de Desenvolvimento Científico e Tecnológico · Delta University for Science and Technology · ECOG-ACRIN Cancer Research Group · Eastern Cooperative Oncology Group · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Father Sean O'Sullivan Research Centre · Fresenius Kabi · Harborview Injury Prevention and Research Center · Health Canada · Hector-Stiftung · Heidelberg University · IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy · Institute of Child Health · LILT (Italian league against cancer) · Medical College of Wisconsin · Michael Dean · Ministry of Health, Brazil · Ministry of Health, France · National Center for Complementary and Integrative Health (NCCIH) · National Eye Institute (NEI) · National Institute of Allergy and Infectious Diseases (NIAID) · North Central Cancer Treatment Group · Ondokuz Mayıs University · Oswaldo Cruz Foundation · Penn State University · Pharco Pharmaceuticals · Prince of Songkla University · Roswell Park Cancer Institute · Schwabe-Wenex International Ltd · Seattle Children's Hospital · Shriners Hospitals for Children · Sphinx university · St. Joseph's Health Care London · Tanta University · The Prostate Cancer Research Foundation of Canada · Unity Health Toronto · University Hospital Birmingham · University of Birmingham · University of California, Los Angeles · University of California, San Francisco · University of North Carolina · University of Oklahoma · University of Pennsylvania · University of Pittsburgh · Ursapharm, Saarbrücken · Yale University

Trials 33 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT04005222 May 2014 → Sep 2016 Beytepe Murat Erdi Eker State Hospital Completed No outcome recorded
Phase 12 trials
Phase 1 NCT01212965 Sep 2010 → Sep 2011 lymphatic malformation Medical College of Wisconsin Terminated No outcome recorded
Phase 1 NCT00217516 Mar 2005 → Feb 2008 prostate cancer Roswell Park Cancer Institute Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT01432873 Jun 2011 → Oct 2012 chemotherapy-induced oral mucositis Tehran University of Medical Sciences Unknown No outcome recorded
Phase 1/2 NCT00010842 Sep 1999 → Dec 2004 multiple sclerosis National Center for Complementary and Integrative Health (NCCIH) Completed No outcome recorded
Phase 27 trials
Phase 2 NCT04869579 Aug → Nov 2021 COVID-19 CHRISTUS Health Unknown No outcome recorded
Phase 2 NCT02421887 Dec 2015 → Jun 2018 male infertility Yale University Completed No outcome recorded
Phase 2 NCT01554345 Jun 2011 → Aug 2012 acute kidney injury Tehran University of Medical Sciences Unknown No outcome recorded
Phase 2 NCT00844792 Oct 2008 → Dec 2013 prostate cancer University Health Network, Toronto Completed No outcome recorded
Phase 2 NCT00744549 May 2008 → Dec 2013 prostate cancer University Health Network, Toronto Completed No outcome recorded
Phase 2 NCT00963131 Dec 2004 → Dec 2008 central serous chorioretinopathy Prince of Songkla University Completed No outcome recorded
Phase 2 NCT00207844 Jan 2002 → Jan 2005 infectious disease with sepsis Centre Hospitalier de Meaux Completed No outcome recorded
Phase 313 trials
Phase 3 NCT05614349 Jan 2023 → Apr 2025 overdue COVID-19 Unity Health Toronto Active not recruiting No outcome recorded
Phase 3 NCT00875173 Oct 2008 → Dec 2016 Chagas disease Oswaldo Cruz Foundation Unknown No outcome recorded
Phase 3 NCT00706121 Jun 2008 → Oct 2015 colorectal cancer, precancerous condition SWOG Cancer Research Network Completed No outcome recorded
Phase 3 NCT00395161 Apr 2007 → Nov 2009 infectious disease with sepsis Michael Dean Terminated No outcome recorded
Phase 3 NCT00553124 Dec 2005 → ? urinary bladder cancer University Hospital Birmingham Unknown No outcome recorded
Phase 3 NCT00553345 Dec 2005 → ? urinary bladder cancer University of Birmingham Unknown No outcome recorded
Phase 3 NCT00784225 Jul 2004 → Nov 2017 cataract, macular degeneration SWOG Cancer Research Network Completed No outcome recorded
Phase 3 NCT00515736 Jan 2003 → Dec 2005 subarachnoid hemorrhage Centre Hospitalier Universitaire Vaudois Terminated No outcome recorded
Phase 3 NCT00006392 Jul 2001 → May 2011 prostate cancer SWOG Cancer Research Network Completed No outcome recorded
Phase 3 NCT00008385 Dec 2000 → Jun 2011 lung cancer ECOG-ACRIN Cancer Research Group Completed No outcome recorded
Phase 44 trials
Phase 4 NCT06362005 May 2024 → Jul 2025 lichen planus, oral Al-Azhar University Completed No outcome recorded
Phase 4 NCT00860379 Jan 2009 → Dec 2019 Shriners Hospitals for Children Terminated No outcome recorded
Phase 4 NCT00186706 Sep 2005 → Nov 2007 cardiovascular disorder, chronic obstructive pulmonary disease St. Joseph's Health Care London Completed No outcome recorded
Phase 4 NCT00160901 Aug 2003 → Dec 2005 breast cancer Heidelberg University Completed No outcome recorded
Phase not applicable4 trials
NCT07334197 Dec 2026 → Dec 2029 expected peripartum cardiomyopathy Tanta University Not yet recruiting No outcome recorded
NCT06042738 Mar → Nov 2021 male infertility Ondokuz Mayıs University Completed No outcome recorded
NCT04942769 Dec 2019 → Jul 2021 Beijing Chao Yang Hospital Unknown No outcome recorded
NCT00378456 trisomy 21 Institute of Child Health Completed No outcome recorded
Also used as a comparator or background therapy in 7 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT02058212 Comparator Mar → Oct 2013 endometriosis Cairo University Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT06117436 Comparator Oct 2023 → Dec 2024 Ain Shams University Completed No outcome recorded
Phase 2/3 NCT03476044 Comparator Jun 2018 → Mar 2020 Assiut University Completed No outcome recorded
Phase 32 trials
Phase 3 NCT04080622 Comparator Oct 2019 → Oct 2023 chemotherapy-induced oral mucositis, disease related to hematopoietic stem cell transplant University Hospital, Angers Completed No outcome recorded
Phase 3 NCT00078897 Comparator Jan 2005 → Jan 2014 adenomatous colon polyp, colorectal cancer, precancerous condition University of Arizona Terminated No outcome recorded
Phase 41 trial
Phase 4 NCT05266794 Comparator Jan → Apr 2019 end stage renal failure Ain Shams University Completed No outcome recorded
Phase not applicable1 trial
NCT06413043 Comparator May 2024 → Aug 2025 endocrine exophthalmos All India Institute of Medical Sciences, Bhubaneswar Unknown No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 42 sources stand behind the page.

FieldValueCited text
Known as Selenium “food supplement containing 2000 mg L-carnitine, 2000 mg fructose, 932 mg acetyl L-carnitine, 225 mg vitamin C, 115 mg citric acid, 50 mg coenzyme Q10, 14 mg zinc, 115 µg...” NCT06042738
39

“Tablet: Vitamin C, 500 mg; Vitamin D3, 1000 IU; Vitamin E, 400 IU; Folic Acid 1000 mcg; Zinc, 20 mg; Selenium 200 mcg; Lycopene, 10 mg; Capsule: Vitamin D3, 1000 IU,...” NCT02421887

“The second therapeutic arm investigates a combination antioxidant therapy (selenium 300 µg, zinc 40 mg, lycopene 45 mg and vitamin C 1.5 g), administered for 10 days.” PMID 40754325 Aug 2025

“Twice a day with meals. Lycopene - 20 mg, Vitamin D3 - 200 IU, Selenium - 100 mcg, Green Tea Extract - 75 mg, Vitamin E - 50 IU” NCT00844792

“daily supplementation with a combination of alpha-tocopherol, vitamin C, and seleniumNCT00339768

“daily oral medication consisting of selenium (sodium-selenit 100 microg/d)” NCT00160901

“tablets composed of 200 mcg selenium \[as l-selenomethionine\]” NCT01437826

“Lycopene, Vitamin D3, Selenium, Green Tea Extract, Vitamin E” NCT00744549

selenium 40 mg” NCT00963131

NCT07334197

NCT00875173

NCT00010842

NCT00078897

NCT00395161

NCT02058212

NCT00553345

NCT01432873

NCT01212965

NCT00006392

NCT04942769

NCT06117436

NCT06413043

NCT00217516

NCT04005222

NCT05266794

NCT04080622

NCT01554345

NCT00553124

NCT00784225

NCT00706121

NCT04869579

NCT03476044

NCT00008385

NCT00186706

NCT00207844

NCT00170404

NCT06362005

NCT00515736

NCT00860379

NCT00378456

Known as Selenium - Laboratoire Aguettant Selenium - Laboratoire AguettantNCT00515736
Known as sodium selenite “Patients received, for 10 days, selenium as sodium selenite (4,000 microg on the first day, 1,000 microg/day on the nine following days) or matching placebo using continuous...” PMID 17617901 2007
Known as sodium-selenit “selenium (sodium-selenit 100 microg/d)” NCT00160901
Modality Other / unclassified “combination of AOX micronutrient supplements” NCT00515736
Route Oral Oral selenium (200 microg/d from L-selenomethionine)” PMID 19066370 Dec 2008