Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma

NCT00302003 ↗

Phase 3 Completed 287 enrolled Children's Oncology Group National Cancer Institute (NCI) · collab

NaSingle-groupOpen-labelTreatment

Summary

This phase III trial is studying how well combination chemotherapy works when given before radiation therapy and/or additional chemotherapy in treating young patients with newly diagnosed Hodgkin's lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill cancer cells. Giving more than one drug (combination chemotherapy) and giving them together with radiation therapy may kill more cancer cells.

Timeline

Start: 2006-02
Primary completion: 2012-03
Completion: 2019-06-30

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cisplatin	Other / unclassified	—	Intravenous
Subject	Cyclophosphamide	Other / unclassified	600 mg/m2	Intravenous
Subject	Cytarabine	Small molecule	—	Intravenous
Subject	Dexamethasone	Small molecule	—	Intravenous
Subject	Doxorubicin	Other / unclassified	25 mg/m2	Intravenous
Subject	Etoposide	Small molecule	—	Intravenous
Subject	Ifosfamide	Small molecule	—	Intravenous
Subject	Prednisone	Other / unclassified	40 mg/m2	Oral
Subject	Vincristine	Small molecule	1.4 mg/m2	Intravenous
Subject	Vinorelbine	Small molecule	—	Intravenous
Background	filgrastim	Protein / enzyme biologic	5 ug/kg	Intravenous

Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma

Summary

Timeline

Publications

Drugs

Indications