Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Phase 4 Completed 102 enrolled Asker & Baerum Hospital

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Total knee arthroplasty (TKA) is associated with moderate to severe postoperative pain, causing patient discomfort, mobilisation and hospital discharge. The aim of this study is to: 1. Compare analgetic efficacy of to types of local infiltration analgesia in total knee arthroplasty. 2. Compare analgetic efficacy of local infiltration analgesia with continuous epidural analgesia.

Timeline

Start: 2007-11
Primary completion: 2009-06
Completion: 2009-07

Publications

Spreng UJ, Dahl V, Hjall A, Fagerland MW, Raeder J. High-volume local infiltration analgesia combined with intravenous or local ketorolac+morphine compared with epidural analgesia after total knee arthroplasty. Br J Anaesth. 2010 Nov;105(5):675-82. doi: 10.1093/bja/aeq232. Epub 2010 Aug 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Bupivacaine	Other / unclassified	—	Other
Comparator	Fentanyl	Other / unclassified	—	Other
Subject	Ketorolac	Other / unclassified	30 mg	Other
Subject	Morphine	Other / unclassified	5 mg	Other
Subject	Ropivacaine	Other / unclassified	150 mg	Other
Background	Epinephrine	Other / unclassified	0.5 mg	Other

Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty

Summary

Timeline

Publications

Drugs

Indications