drugset / Trial / NCT02164929
Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic Colectomy
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to assess the effectiveness of transversus abdominal plane (TAP) block, thoracic epidural or paravertebral block (PVB) for controlling postoperative pain when compared with opioid you self-administer in your vein using a PCA device. The primary outcome will be postoperative opioid consumption within 24 hours after surgery. A total of 120 subjects will be randomized in a 1:1:1:1 ratio to receive a TAP block, PVB, TEA or no block (PCA alone).Patients in all groups will be cared for using an established enhanced recovery after surgery (ERAS) pathway incorporating a multimodal analgesic regimen using IV acetaminophen and postoperative PCA fentanyl.
Timeline
- Start
- 2013-12
- Primary completion
- 2015-03
- Completion
- 2015-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 1 g | Intravenous |
| Comparator | Dexamethasone | Small molecule | 4 mg | Intravenous |
| Comparator | Epinephrine | Other / unclassified | — | — |
| Comparator | Hydromorphone | Other / unclassified | 400 ug | Other |
| Comparator | Hydromorphone | Other / unclassified | 800 ug | Other |
| Comparator | Lidocaine | Other / unclassified | 1.5 % | — |
| Comparator | Midazolam | Small molecule | 2 mg | — |
| Comparator | Propofol | Small molecule | 1 mg/kg | — |
| Comparator | Propofol | Small molecule | 2.5 mg/kg | — |
| Comparator | Ropivacaine | Other / unclassified | 0.25 % | Other |
| Comparator | Ropivacaine | Other / unclassified | 10 ml | Other |
| Comparator | Sevoflurane | Other / unclassified | — | — |
Indications
No indication recorded.