drugset
drugset / Trial / NCT03013075

General Plus Spinal Anesthesia and General Anesthesia Alone on Right Ventricular Function

NCT03013075 ↗

Phase 4 Unknown 50 enrolled Post Graduate Institute of Medical Education and Research, Chandigarh
RandomizedParallel-groupOpen-labelSupportive care

Summary

The investigator hypothesize that High Spinal Anesthesia (HSA) by its effect on attenuation of stress response, decrease in pulmonary vascular resistance, myocardial protection and positive myocardial oxygen balance will cause improvement in right ventricular function. So far there is no study that has evaluated the effect of HSA anesthesia on the right ventricular function, hence the investigator planned this study to compare the effect of HSA on the right ventricular function in patients with mitral valve disease with moderate to severe pulmonary hypertension planned for mitral valve replacement surgery.

Timeline

Start
2016-11
Primary completion
2017-12
Completion
2017-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Bupivacaine Other / unclassified 40 mg Intrathecal
Subject Morphine Other / unclassified 250 ug Intrathecal
Background Fentanyl Other / unclassified 2 ug/kg —
Background Isoflurane Other / unclassified — Inhaled
Background Lidocaine Other / unclassified 10 % Topical
Background Midazolam Small molecule 1 mg —
Background Midazolam Small molecule 2 mg —
Background Propofol Small molecule — —
Background Vecuronium Small molecule 0.1 mg/kg —

Indications

No indication recorded.