Drugs / Hydrogen Peroxide
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Hydrogen Peroxide

Small molecule

Developed for
common wart · COVID-19 · seborrheic keratosis · tooth disorder · chronic periodontitis · periodontal disorder · periodontitis · basal cell carcinoma
+18 more · breast cancer · cervical cancer · dental fluorosis · dentin sensitivity · dermatosis papulosa nigra · female breast carcinoma · gingival disorder · gingivitis · mucositis · placenta accreta · plantar wart · pleural empyema · prosthesis-related infectious disease · pulpitis · respiratory tract infectious disorder · skin squamous cell carcinoma · bacterial infectious disease · dental caries
Investigated by
Aclaris Therapeutics, Inc. · First Hospital of China Medical University · Kortuc, Inc. · Colgate Palmolive · Institute of Cancer Research, United Kingdom · University of Chile
+41 more · Aga Khan University · André Luis Faria e Silva · Assiut University · BMG Pharma · CMH Multan Institute of Medical Sciences · Cairo University · Charles University, Czech Republic · Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. · Cukurova University · Delta University for Science and Technology · Dentaid SL · Dental School · FISABIO Foundation · Federal University of Minas Gerais · Federal University of Uberlandia · Fundação de Amparo à Pesquisa do estado de Minas Gerais · GlaxoSmithKline · Hospital Clínico Universitario de Valencia · Hospital Universitario Fundación Jiménez Díaz · Hospital Universitario General de Villalba · Hospital Universitario Infanta Elena · Hospital Universitario Virgen de la Arrixaca · JDC Tech · Jordan University of Science and Technology · King Abdullah University Hospital · Krishnadevaraya College of Dental Sciences & Hospital · Loma Linda University · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Madigan Army Medical Center · Pakistan Institute of Medical Sciences · Perio Protect LLC · Plovdiv Medical University · Queen Mary University of London · Ramziyah Hayder Bakr · Rowpar Pharmaceuticals, Inc. · The University of Texas Health Science Center, Houston · United States Department of Defense · University of California, San Francisco · University of Karachi · University of Milan · University of Oklahoma

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) ESKATA — 2017-12-14 fda.gov ↗

Trials 46

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 02 trials
Phase 0 NCT05669560 Jan 2023 → May 2027 chronic periodontitis, type 2 diabetes mellitus University of Oklahoma Withdrawn No outcome recorded
Phase 0 NCT05024760 Jul 2022 → Nov 2025 overdue mucositis, periodontitis, prosthesis-related infectious disease Madigan Army Medical Center Recruiting No outcome recorded
Phase 12 trials
Phase 1 NCT05570422 Mar 2026 → Jan 2027 expected cervical cancer Kortuc, Inc. Recruiting No outcome recorded
Phase 1 NCT06404190 May → Aug 2023 periodontitis Krishnadevaraya College of Dental Sciences & Hospital Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT02757651 Jan 2017 → Nov 2020 female breast carcinoma Institute of Cancer Research, United Kingdom Completed No outcome recorded
Phase 28 trials · 1 met primary · 1 missed
Phase 2 NCT07713329 Mar → Jun 2026 pleural empyema, respiratory tract infectious disorder Delta University for Science and Technology Completed No outcome recorded
Phase 2 NCT04929535 Sep 2022 → Aug 2023 basal cell carcinoma, skin squamous cell carcinoma London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Unknown No outcome recorded
Phase 2 NCT04409873 Mar 2021 → Sep 2022 COVID-19, disorder of pharynx University of California, San Francisco Terminated Missed primary Stop: Enrollment
Phase 2 NCT03946202 Jun 2020 → Aug 2028 expected breast cancer Institute of Cancer Research, United Kingdom Active not recruiting No outcome recorded
Phase 2 NCT03210337 Aug 2017 → Mar 2018 common wart Aclaris Therapeutics, Inc. Completed No outcome recorded
Phase 2 NCT03278028 Jul 2017 → Mar 2018 common wart Aclaris Therapeutics, Inc. Completed No outcome recorded
Phase 2 NCT03224598 Jun 2017 → Jan 2019 dermatosis papulosa nigra Aclaris Therapeutics, Inc. Completed No outcome recorded
Phase 2 NCT02669862 Dec 2015 → Sep 2016 common wart Aclaris Therapeutics, Inc. Completed Met primary
Phase 311 trials · 2 met primary
Phase 3 NCT07830979 Sep 2026 → Sep 2027 expected plantar wart Assiut University Not yet recruiting No outcome recorded
Phase 3 NCT07276672 Nov 2025 — Colgate Palmolive Completed No outcome recorded
Phase 3 NCT06957249 Apr → May 2025 — Colgate Palmolive Completed No outcome recorded
Phase 3 NCT07351370 Jan → Jul 2022 periodontal disorder Dental School Completed No outcome recorded
Phase 3 NCT04438434 Jun → Jul 2020 impacted teeth, multiple University of Milan Unknown No outcome recorded
Phase 3 NCT03812510 Feb → Nov 2019 common wart Aclaris Therapeutics, Inc. Completed No outcome recorded
Phase 3 NCT03687372 Sep 2018 → Jun 2019 common wart Aclaris Therapeutics, Inc. Completed Met primary
Phase 3 NCT03691831 Sep 2018 → Apr 2019 common wart Aclaris Therapeutics, Inc. Completed Met primary
Phase 3 NCT02667275 Jan → Oct 2016 seborrheic keratosis Aclaris Therapeutics, Inc. Completed No outcome recorded
Phase 3 NCT02667288 Jan → Oct 2016 seborrheic keratosis Aclaris Therapeutics, Inc. Completed No outcome recorded
Phase 46 trials
Phase 4 NCT06045429 May 2024 → Jun 2025 overdue — Charles University, Czech Republic Recruiting No outcome recorded
Phase 4 NCT04659928 Jul 2021 → May 2024 COVID-19 The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase 4 NCT04407910 Sep 2018 → Mar 2019 dental fluorosis Cukurova University Completed No outcome recorded
Phase 4 NCT03514797 Apr → Jun 2018 tooth disorder André Luis Faria e Silva Completed No outcome recorded
Phase 4 NCT03262701 Apr 2018 → Feb 2021 chronic periodontitis Loma Linda University Terminated No outcome recorded
Phase 4 NCT03487588 Mar → Nov 2018 seborrheic keratosis Aclaris Therapeutics, Inc. Completed No outcome recorded
Phase not applicable16 trials · 1 missed
— NCT07534865 May 2026 → Dec 2028 expected common wart First Hospital of China Medical University Recruiting No outcome recorded
— NCT07565350 Oct 2025 → Oct 2027 expected common wart First Hospital of China Medical University Recruiting No outcome recorded
— NCT07031388 Jul → Sep 2025 gingival disorder Ramziyah Hayder Bakr Completed No outcome recorded
— NCT07486245 Mar → Nov 2025 pulpitis CMH Multan Institute of Medical Sciences Completed No outcome recorded
— NCT06904118 Jun → Dec 2024 dentin sensitivity Pakistan Institute of Medical Sciences Completed No outcome recorded
— NCT07287956 Feb 2024 → Jul 2025 periodontal disorder King Abdullah University Hospital Completed No outcome recorded
— NCT06030492 Jan → Sep 2023 placenta accreta Cairo University Unknown No outcome recorded
— NCT06812065 Dec 2022 → Dec 2026 expected common wart First Hospital of China Medical University Recruiting No outcome recorded
— NCT04341688 Dec 2021 → Jun 2022 COVID-19 Aga Khan University Unknown No outcome recorded
— NCT04723446 May → Oct 2021 COVID-19 Queen Mary University of London Completed No outcome recorded
Comparator or background therapy27 trials
Phase 0 NCT03678012 Comparator Jun → Aug 2018 dental caries University of Pennsylvania Completed No outcome recorded
Phase 1 NCT03434782 Background Apr → Nov 2017 dentin sensitivity Federal University of Pará Completed No outcome recorded
Phase 1 NCT03044171 Background Aug 2016 → Jan 2017 dentin sensitivity Federal University of Pará Completed No outcome recorded
Phase 1 NCT01008111 Comparator Oct 2009 → Apr 2013 — Wake Forest University Withdrawn No outcome recorded
Phase 1/2 NCT01986920 Comparator Oct 2013 → Feb 2014 seborrheic keratosis Aclaris Therapeutics, Inc. Completed No outcome recorded

News releases announcing trial results or a regulatory action · 23

DateIssuerRelease
2026-05-14 Kortuc, Inc. Results KORTUC Basic Research Published in Clinical and Translational Radiation Oncology kortuc.com ↗
Specifically, the study showed that KORTUC promoted immunogenic cell death, preserved T-cell function within tumors, and selectively reduced immunosuppressive M2-like macrophages.
2025-01-07 Kortuc, Inc. Results KORTUC’s Basic Research Published in The Green Journal kortuc.com ↗
The study, titled “Revisiting Hydrogen Peroxide as a Radiosensitizer for Solid Tumor Cells,” demonstrates that KORTUC suppresses oxygen consumption in hypoxic tumor cells via mitochondrial pathways, restores oxygen levels, and significantly enhances the effects of radiotherapy.
2024-10-12 Kortuc, Inc. Results A new article of KORTUC (KRC-01) was published in ”BJC Reports” kortuc.com ↗
This article demonstrates tumour reoxygenation by KORTUC in vitro/in vivo model, and shows its promising potential of KORTUC for the treatment of hypoxic tumors across various cancer types.
2023-05-29 Kortuc, Inc. Results KRC-01’s new basic research result will be presented at International Wolfsberg Meeting kortuc.com ↗
In this study, it was shown that the radiosensitizing effect of H2O2 under hypoxic conditions can be attributed to the inhibition of cellular respiration through a complex I (exist on the inner mitochondrial membrane) blockade, in addition to reoxygenating cells.
2023-04-13 Kortuc, Inc. Results KRC-01’s new basic research result will be presented at ESTRO2023 kortuc.com ↗
In this study, it was shown that the radiosensitizing effect of H2O2 under hypoxic conditions can be attributed to the inhibition of cellular respiration through a complex I (exist on the inner mitochondrial membrane) blockade, in addition to reoxygenating cells.
2022-09-29 Kortuc, Inc. Results KORTUC’s new basic research result will be presented at BACR2022 kortuc.com ↗
In this study, it was shown for the first time that the radiosensitizing effect of H2O2 under hypoxic conditions can be attributed to the inhibition of cellular respiration, in addition to reoxygenating cells.
2019-10-24 Aclaris Therapeutics, Inc. Results Aclaris Therapeutics’ A-101 45% Topical Solution Meets Primary and All Secondary Efficacy Endpoints in Second Successful Pivotal Phase 3 Clinical Trial for the Treatment of Common Warts (THWART-1) aclaristx.com ↗
A-101 45% met the primary and all secondary efficacy endpoints, achieving clinically meaningful and statistically significant clearance of common warts.
2019-09-16 Aclaris Therapeutics, Inc. Results Aclaris Therapeutics’ A-101 45% Topical Solution Meets Primary and All Secondary Efficacy Endpoints in Pivotal Phase 3 Trial for the Treatment of Common Warts (THWART-2) aclaristx.com ↗
A-101 45% Topical Solution met the primary and all secondary efficacy endpoints, achieving clinically and statistically significant clearance of common warts.
2019-02-28 Aclaris Therapeutics, Inc. Regulatory Aclaris Therapeutics Receives European Approvals of ESKATA® (hydrogen peroxide) cutaneous solution, 685 mg aclaristx.com ↗
Aclaris also has received approval to market the medicine in the United Kingdom , Iceland , Belgium , and Finland .
2018-06-12 Aclaris Therapeutics, Inc. Results Phase 3 data in the online Journal of the American Academy of Dermatology show Aclaris' ESKATA™ is safe and effective in treating persons with raised seborrheic keratoses aclaristx.com ↗
2018-03-29 Aclaris Therapeutics, Inc. Results Topical Solution May Be Less Toxic Option for Patients with Noncancerous Skin Growth aclaristx.com ↗
The findings were recently published in the Journal of the American Academy of Dermatology.
2018-03-19 Aclaris Therapeutics, Inc. Results Aclaris Therapeutics Announces Positive Update on Phase 2 Results after a 3-month Follow-Up of A-101 45% Topical Solution for Potential Treatment of Common Warts aclaristx.com ↗
Over the 3-month post-treatment follow-up period, greater improvements in common wart reduction and clearance vs. placebo were observed among subjects treated with A-101 45%.

All press releases naming this drug 35 releases

DateIssuerRelease

Evidence & citations 22 cited values

Every value below carries the sentence it was read from. 75 sources stand behind the page.

FieldValueCited text
Known as Hydrogen Peroxide “A Phase 2 Randomized, Double-Blind, Vehicle-Controlled, Parallel Group Study of the Safety and Effectiveness of A-101(Hydrogen Peroxide) Topical Solution in Subjects With...” NCT03148691 ↗
62

“An Open-Label Study Assessing Subject Satisfaction With A-101 Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment for Seborrheic Keratoses of the Face, Neck, and Decolletage” NCT03487588 ↗

“Evaluate the safety and efficacy of hydrogen peroxide, A-101 Solution 40% for the treatment of DPN lesions on subjects with a Fitzpatrick Skin Type of 5 or 6.” NCT03224598 ↗

“KRC-01 is a solution that contains hydrogen peroxide 3% with sodium hyaluronate 1%. Hydrogen peroxide is the active ingredient for this radiosensitizer.” NCT05570422 ↗

“Three 15-minute applications of the 35% hydrogen peroxide gel were performed, totaling 45 minutes in each of the 4 sessions, with a 7-day interval.” NCT03044171 ↗

“Three 15-minute applications of the 35% hydrogen peroxide gel were performed, totaling 45 minutes in each of the 3 sessions, with a 7-day interval.” NCT03434782 ↗

“Participants will receive in-office tooth bleaching with 40% hydrogen peroxide (Opalescence Boost PF 40%) for the maxillary anterior teeth” NCT03163069 ↗

“In one group, the hemiarcade was bleached with 37.5% hydrogen peroxide (Polaoffice + 37.5% SDI Limited, Bayswater, Australia).” NCT03217994 ↗

“Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide” NCT07276672 ↗

“A 40% hydrogen peroxide bleaching agent was applied twice for 15 min for the in-office bleaching treatment.” PMID 34145478 ↗ Jun 2021

“In-office tooth bleaching with 35% hydrogen peroxide in a single application of 45 minutes.” NCT03514797 ↗

Show 52 more sources

Known as A-101 “An Open-Label Study Assessing Subject Satisfaction With A-101 Hydrogen Peroxide Topical Solution, 40% (w/w) Treatment for Seborrheic Keratoses of the Face, Neck, and Decolletage” NCT03487588 ↗
11

“Evaluate the safety and efficacy of hydrogen peroxide, A-101 Solution 40% for the treatment of DPN lesions on subjects with a Fitzpatrick Skin Type of 5 or 6.” NCT03224598 ↗

“A-101 45% (hydrogen peroxide 45% topical solution)” NCT03691831 ↗

NCT03210337 ↗

NCT03148691 ↗

NCT01986920 ↗

NCT02667288 ↗

NCT03278028 ↗

NCT02160626 ↗

NCT02669862 ↗

NCT03812510 ↗

Show 1 more source

Known as ActiveOxy “1% Hydrogen peroxide (HP® by Karachi Chemicals Products Inc./ ActiveOxy® by Boumatic Inc.)” PMID 32928313 ↗ Sep 2020
Known as Crystacide ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as Eskata ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as H2O2 “Hydrogen peroxide (H2O2): Helps remove debris physically and has some antimicrobial activity, though its efficacy against bacteria is less well established.” NCT07486245 ↗
6

“Vigorously rinse with 15 ml of the 1.5% hydrogen peroxide (H2O2) (Peroxyl; Colgate-Palmolive, Guildford, UK) for 30 s” NCT04721457 ↗

“rinsing with: Group 1-0.2% Chlorhexidine digluconate (CHX); Group 2-1.5% Hydrogen peroxide (H2O2);” PMID 37542087 ↗ Aug 2023

“Hydrogen peroxide (H2O2) is a commonly used disinfectant for skin debridement.” NCT06812065 ↗

“hydrogen peroxide (H2O2) and hyaluronic acid (HA) combination formulation” PMID 39012233 ↗ Jul 2024

“Intrapleural Hydrogen Peroxide (H_2O_2)” NCT07713329 ↗

“Hydrogen Peroxide ( H2O2)” NCT06030492 ↗

Known as Hioxyl ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as HP40 “40% (w/w) hydrogen peroxide topical solution (HP40).” PMID 30365590 ↗ Oct 2018
Known as Hydrogen peroxide solution ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as Hyrogen peroxide ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as NSC-19892 ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as Opalescence Boost PF 40% “Participants will receive in-office tooth bleaching with 40% hydrogen peroxide (Opalescence Boost PF 40%) for the maxillary anterior teeth” NCT03163069 ↗
Known as Oroxid “3% hydrogen peroxide (Oroxid®) versus standard of care (0.2% chlorhexidine digluconate)” NCT06045429 ↗
Known as Oximen 3% “Hydrogen peroxide 1% (Oximen® 3%) (Reig Jofré, S.A., Spain).” NCT04707742 ↗
Known as Oxydol ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as Perio Gel “administer 1.7% hydrogen peroxide gel (Perio Gel®, QNT Anderson, Bismarck, ND) deep into the periodontal pocket” NCT05669560 ↗
Known as Peroxyl ChEMBL registry synonym — accepted as the source's own label CHEMBL71595 ↗
Known as Whiteness HP “The handling of 35% hydrogen peroxide (Whiteness HP, FGM, Joinville, SC, Brazil) followed the manufacturer's recommendations, which consisted of mixing 3 drops of 35%hydrogen...” NCT03019224 ↗
Known as Whiteness HP Maxx “A 35% hydrogen peroxide based bleaching agent (Whiteness HP Maxx, FGM, Joinville, SC, Brazil) will be mixed and applied on the vestibular surface of teeth, in the ratio of 1...” NCT02935114 ↗
Action Inhibit “helps in reducing bacterial load” NCT07031388 ↗
Modality Small molecule — CHEMBL71595 ↗
Route Topical “when applied topically up to 2 times to SK target lesions on the face.” NCT02260180 ↗