Drugs / Dulaglutide
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Dulaglutide

Peptide targets GLP1R via activation

Developed for
type 2 diabetes mellitus · obesity disorder · chronic kidney disease · diabetes mellitus · diabetic kidney disease · glucose intolerance · hyperglycemia · bipolar disorder
+14 more · cardiovascular disorder · cystic fibrosis · exocrine pancreatic insufficiency · fatty liver disease · intracranial arteriosclerosis · ischemic stroke · metabolic dysfunction-associated steatohepatitis · metabolic dysfunction-associated steatotic liver disease · physiological sexual disorder · polycystic ovary syndrome · primary polydipsia · type 1 diabetes mellitus · atherosclerotic cardiovascular disease · menstrual disorder
Investigated by
Eli Lilly and Company · Emory University · Innovent Biologics (Suzhou) Co. Ltd. · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · University Hospital, Basel, Switzerland · Ain Shams University
+37 more · Ali Aminian · Berry Consultants · CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. · Central Hospital, Nancy, France · Centre Hospitalier Universitaire Dijon · Children's Hospital Colorado · Children's Hospital of Philadelphia · Dasman Diabetes Institute · Dongguan HEC Biopharmaceutical R&D Co., Ltd. · Elaine Chow · Ethicon, Inc. · European Union · First Affiliated Hospital of Wannan Medical College · First Affiliated Hospital of Zhejiang University · Fundación para la Investigación del Hospital Clínico de Valencia · Goldschmidt-Jacobson Foundation · Hospices Civils de Lyon · Instituto de Salud Carlos III · Medanta, The Medicity, India · National Institute of General Medical Sciences (NIGMS) · National Institutes of Health (NIH) · National University of Singapore · Novo Nordisk A/S · Research Grants Council, Hong Kong · Seoul National University Bundang Hospital · Shanghai 10th People's Hospital · Swiss National Science Foundation · Tessella Inc. · The Affiliated Hospital of Xuzhou Medical University · The University of Hong Kong · The University of Texas Health Science Center, Houston · United BioSource, LLC · University of Palermo · University of Pennsylvania · VA Tennessee Valley Health Care System · Vanderbilt University Medical Center · iRhythm Technologies, Inc.

Regulatory milestones approvals, filings & regulatory actions · 8 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (6) US (FDA) TRULICITY 2017-01-27 – 2022-11-17 fda.gov
Approved EU (EMA) Trulicity 2014-11-21 europa.eu
Approved US (FDA) TRULICITY 2014-09-18 fda.gov

Trials 73 · started per year

today
US approved 2014
EU approved 2014
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200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 114 trials
Phase 1 NCT07313813 Dec 2025 → Aug 2026 overdue type 2 diabetes mellitus Eli Lilly and Company Active not recruiting No outcome recorded
Phase 1 NCT03363906 Dec 2017 → Jun 2018 Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01667900 Aug 2012 → Jun 2014 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01524770 Mar → Jun 2012 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01458210 Oct 2011 → Feb 2012 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01436201 Sep → Nov 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01432938 Sep → Dec 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01408888 Aug 2011 → Apr 2012 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01324388 Mar → Aug 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01301092 Feb → Aug 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT04466904 Sep 2020 → May 2021 type 2 diabetes mellitus Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 212 trials
Phase 2 NCT07370922 Nov 2024 → Nov 2025 beta-thalassemia major Ain Shams University Completed No outcome recorded
Phase 2 NCT06148649 Dec 2023 → Feb 2025 type 2 diabetes mellitus Dongguan HEC Biopharmaceutical R&D Co., Ltd. Completed No outcome recorded
Phase 2 NCT05254418 Mar 2022 → May 2024 chronic kidney disease Vanderbilt University Medical Center Completed No outcome recorded
Phase 2 NCT04731272 Jul 2021 → Jun 2027 expected cystic fibrosis, diabetes mellitus, exocrine pancreatic insufficiency, glucose intolerance University of Pennsylvania Recruiting No outcome recorded
Phase 2 NCT04687514 May 2021 → Sep 2022 physiological sexual disorder University Hospital, Basel, Switzerland Completed No outcome recorded
Phase 2 NCT03668470 Jan 2019 → Feb 2021 type 1 diabetes mellitus Hospices Civils de Lyon Completed No outcome recorded
Phase 2 NCT02973100 Dec 2016 → Jul 2017 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT02770885 Mar 2016 → May 2019 primary polydipsia University Hospital, Basel, Switzerland Completed No outcome recorded
Phase 2 NCT01149421 Jun 2010 → Sep 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT01001104 Oct 2009 → Dec 2010 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT07282041 Dec 2025 → Dec 2030 expected intracranial arteriosclerosis, ischemic stroke National University of Singapore Recruiting No outcome recorded
Phase 2/3 NCT00734474 Aug 2008 → Jun 2011 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 323 trials
Phase 3 NCT06739122 Jan 2025 → Dec 2027 expected type 2 diabetes mellitus Eli Lilly and Company Recruiting No outcome recorded
Phase 3 NCT06235086 Apr 2024 → Feb 2026 type 2 diabetes mellitus CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. Completed No outcome recorded
Phase 3 NCT05606913 Jan 2023 → Jan 2024 type 2 diabetes mellitus Innovent Biologics (Suzhou) Co. Ltd. Completed No outcome recorded
Phase 3 NCT04809220 Apr 2021 → Oct 2022 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT04591626 Dec 2020 → Apr 2022 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT04255433 May 2020 → Jun 2025 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT03495102 Apr 2018 → May 2019 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT02963766 Dec 2016 → Jun 2021 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT02597049 Nov 2015 → Feb 2017 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT02152371 May 2014 → Oct 2015 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 417 trials
Phase 4 NCT07027969 Nov 2026 → Dec 2029 expected atrial fibrillation, obesity disorder Ali Aminian Not yet recruiting No outcome recorded
Phase 4 NCT07537088 May 2026 → Apr 2027 expected chronic kidney disease, type 2 diabetes mellitus First Affiliated Hospital of Wannan Medical College Not yet recruiting No outcome recorded
Phase 4 NCT06851962 May 2025 → Jun 2026 overdue type 2 diabetes mellitus Fundación para la Investigación del Hospital Clínico de Valencia Active not recruiting No outcome recorded
Phase 4 NCT06324461 Mar 2024 → Dec 2028 expected The University of Hong Kong Recruiting No outcome recorded
Phase 4 NCT05140694 Dec 2023 → Jun 2024 metabolic dysfunction-associated steatotic liver disease, type 2 diabetes mellitus Seoul National University Bundang Hospital Unknown No outcome recorded
Phase 4 NCT05659537 Dec 2022 → Jan 2024 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 4 NCT05218915 Jan 2022 → Oct 2024 diabetes mellitus, diabetic kidney disease Elaine Chow Completed No outcome recorded
Phase 4 NCT04862234 Aug 2021 → Jun 2023 hyperglycemia Emory University Terminated No outcome recorded
Phase 4 NCT04876027 May 2021 → Apr 2022 polycystic ovary syndrome Shanghai 10th People's Hospital Completed No outcome recorded
Phase 4 NCT04387201 May 2020 → Oct 2023 glucose intolerance, obesity disorder The University of Texas Health Science Center, Houston Completed No outcome recorded
Phase not applicable4 trials
NCT06331286 Sep 2023 → Dec 2024 bipolar disorder, obesity disorder First Affiliated Hospital of Zhejiang University Unknown No outcome recorded
NCT06182891 Oct 2021 → Jun 2023 diabetic kidney disease The Affiliated Hospital of Xuzhou Medical University Completed No outcome recorded
NCT03590626 Jan 2019 → Jan 2020 fatty liver disease, type 2 diabetes mellitus Medanta, The Medicity, India Completed No outcome recorded
NCT03498001 Apr 2018 → Jun 2023 type 2 diabetes mellitus Centre Hospitalier Universitaire Dijon Completed No outcome recorded
Also used as a comparator or background therapy in 40 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT05516966 Comparator Oct 2022 → May 2023 type 2 diabetes mellitus Fujian Shengdi Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 1 NCT05407961 Background Jun 2022 → Jan 2024 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT05377333 Background Jun 2022 → Nov 2023 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT05459285 Comparator May → Jul 2022 type 2 diabetes mellitus Sunshine Lake Pharma Co., Ltd. Completed No outcome recorded
Phase 1 NCT04641312 Background Nov 2020 → Dec 2021 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT07319286 Comparator Aug 2025 → Dec 2026 expected menstrual disorder, type 1 diabetes mellitus Ain Shams University Enrolling by invitation No outcome recorded
Phase 211 trials
Phase 2 NCT07677891 Comparator Oct 2026 → May 2027 expected type 2 diabetes mellitus ProGen. Co., Ltd. Not yet recruiting No outcome recorded
Phase 2 NCT07109700 Comparator Apr 2025 → Jan 2026 overdue type 2 diabetes mellitus Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06901648 Comparator Feb 2024 → Mar 2025 type 2 diabetes mellitus Jiangsu Hansoh Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 2 NCT05478707 Comparator Oct 2023 → Jun 2028 type 1 diabetes mellitus University of Virginia Suspended No outcome recorded
Phase 2 NCT05348122 Comparator Jun 2022 → Nov 2023 type 2 diabetes mellitus CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. Unknown No outcome recorded
Phase 39 trials
Phase 3 NCT07668336 Comparator Sep 2026 → Mar 2030 expected type 2 diabetes mellitus Eli Lilly and Company Not yet recruiting No outcome recorded
Phase 3 NCT07156539 Comparator Sep 2025 → Mar 2027 expected type 2 diabetes mellitus Jiangsu Hansoh Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT06257966 Comparator Jul 2024 → Oct 2026 expected type 2 diabetes mellitus Beijing Dongfang Biotech Co., Ltd. Active not recruiting No outcome recorded
Phase 3 NCT05680129 Comparator Jan 2023 → Jul 2024 type 2 diabetes mellitus Hangzhou Sciwind Biosciences Co., Ltd. Completed No outcome recorded
Phase 3 NCT03861052 Comparator May 2019 → Mar 2021 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 48 trials
Phase 4 NCT07325435 Comparator Dec 2024 → Dec 2027 expected type 2 diabetes mellitus MaryAnn Banerji Active not recruiting No outcome recorded
Phase 4 NCT06449235 Comparator Sep 2024 → Apr 2025 overdue type 2 diabetes mellitus Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders Not yet recruiting No outcome recorded
Phase 4 NCT06533527 Comparator Jul 2024 → May 2025 gastroparesis, obesity disorder, type 2 diabetes mellitus The Cleveland Clinic Completed No outcome recorded
Phase 4 NCT05564039 Comparator Nov 2022 → Jul 2024 type 2 diabetes mellitus Eli Lilly and Company Completed No outcome recorded
Phase 4 NCT05390892 Comparator Sep 2022 → Mar 2029 expected atherosclerotic cardiovascular disease, type 2 diabetes mellitus Brigham and Women's Hospital Recruiting No outcome recorded
Phase not applicable3 trials
NCT04829903 Comparator Jan 2020 → Mar 2021 obesity disorder, type 2 diabetes mellitus Corporacion Parc Tauli Completed No outcome recorded
NCT06611904 Comparator Feb 2018 → Feb 2022 overdue arteriosclerosis disorder, proteinuria Attikon Hospital Active not recruiting No outcome recorded
NCT02846233 Comparator Aug 2016 → Dec 2018 type 2 diabetes mellitus University of California, San Francisco Completed No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2018-09-20 Novo Nordisk A/S Novo Nordisk - Oral semaglutide demonstrates greater reductions in HbA1c and body weight and comparable number of adverse events vs dulaglutide in Japanese people with type 2 diabetes novonordisk.com
2017-08-16 Novo Nordisk A/S Semaglutide superior to dulaglutide on glucose control and weight loss in people with type 2 diabetes in SUSTAIN 7 novonordisk.com

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 117 sources stand behind the page.

FieldValueCited text
Known as Dulaglutide “A Phase 2, 12-Week, Double-Blind, Randomized, Parallel Group, Multi-Centre Study to Evaluate Efficacy and Safety of GX-G6 on Glycaemic Control Versus Placebo and Open-Label...” NCT03962010
94

“The potential effect of the GLP-1 RA dulaglutide on the pharmacokinetics (PK) of four orally administered drugs and on the pharmacodynamic (PD) effect of warfarin was investigated.” PMID 28357715 Nov 2017

“Chemical Name: GLP-1 Receptor Agonists (GLP1RA) (e.g., Exenatide, Liraglutide, Dulaglutide, Semaglutide) Class: Glucagon-Like Peptide-1 Receptor Agonists” NCT06449235

“This study in healthy men and women looks at the injection site experience of semaglutide and dulaglutide given subcutaneously (s.c., under the skin).” NCT04189848

“The choice of AOMs considered may include metformin, topiramate, liraglutide, dulaglutide, semaglutide, tirzepatide, and empagliflozin.” NCT07027969

“LY2189265 (Dulaglutide): 1.5 milligrams (mg), subcutaneously (SC), once weekly for 52 weeks” NCT01126580

“Liraglutide: 6 mg/ml Semaglutide: 1.34 mg/ml Dulaglutide: de 0.75 mg ou 1.5 mg” NCT03498001

“Albiglutide (Tanzeum) or , Dulaglutide (Trulicity)” NCT02846233

Dulaglutide, liraglutide, semaglutide” NCT05390892

dulaglutide 1.5 mg per week” NCT04135287

dulaglutide (Trulicity)” NCT07325435

DulaglutideNCT04876027

NCT01436201

NCT06533527

NCT04731272

NCT07537088

NCT04387201

NCT05254418

NCT04867785

NCT06611904

NCT07313813

NCT05005741

NCT05459285

NCT02770885

NCT07282041

NCT04809220

NCT01667900

NCT01458210

NCT03495102

NCT03590626

NCT03444142

NCT04687514

NCT01621178

NCT03315780

NCT02973100

NCT05048719

NCT07156539

NCT05606913

NCT05377333

NCT01769378

NCT06235086

NCT01524770

NCT04515576

NCT07677891

NCT05348122

NCT06182891

NCT02152371

NCT01394952

NCT03684642

NCT04862234

NCT07370922

NCT01644500

NCT02963766

NCT03204396

NCT07319286

NCT05218915

NCT04255433

NCT06257966

NCT03824002

NCT03648554

NCT04893148

NCT06851962

NCT06148649

NCT05407961

NCT05478707

NCT06901648

NCT06331286

NCT03743025

NCT02759107

NCT01432938

NCT05680129

NCT04641312

NCT01648582

NCT03131687

NCT02787551

NCT03668470

NCT05659537

NCT02648204

NCT03861052

NCT02750410

NCT02597049

NCT03015220

NCT04466904

NCT06739122

NCT03141632

NCT07668336

NCT04829903

NCT05564039

NCT03363906

NCT06324461

NCT05516966

NCT05140694

NCT07109700

NCT04591626

NCT04143802

Known as Dulaglutida ChEMBL registry synonym — accepted as the source's own label CHEMBL2108027
Known as dulaglutide (Trulicity) dulaglutide (Trulicity)NCT07325435
Known as Dulaglutide component of trulicity ChEMBL registry synonym — accepted as the source's own label CHEMBL2108027
Known as dulaglutide injection “Drug: dulaglutide injectionNCT06331286
1

“Drug: Dulaglutide InjectionNCT06182891

Known as LY2189265 “A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus” NCT02597049
20

“Dulaglutide (LY2189265)” NCT07313813

NCT01126580

NCT01468181

NCT00734474

NCT01301092

NCT01191268

NCT01584232

NCT00791479

NCT01149421

NCT00630825

NCT01001104

NCT01624259

NCT01324388

NCT01215968

NCT01064687

NCT01408888

NCT01558271

NCT01253304

NCT01075282

NCT01300260

Known as TRULICITY “Dulaglutide (Trulicity®) 1.5 mg in 0.5 ml, via Pen s.c. once weekly for 3 weeks.” NCT03141632
1

“dulaglutide (TRULICITY®) 1.5 mg” NCT03648554

Action Activate “once-weekly glucagon-like peptide-1 (GLP-1) receptor agonist” PMID 24762094 May 2014
Modality Peptide “a synthetic once-weekly, injectable human glucagon-like peptide 1 analogue” PMID 28573765 Jul 2017
Route Subcutaneous subcutaneous (SC) injection” NCT00630825
Target GLP1R “injectable GLP-1RA dulaglutide 0.75 mg” PMID 33460016 Jan 2021