Drugs / Nesuparib
last change Jul 2026 re-read 2 minutes ago

Nesuparib

also known as JPI-547 · NOV140201

Small molecule targets PARP1 via inhibition

Developed for
ovarian cancer · cancer · endometrial carcinoma · gastric cancer · pancreatic ductal adenocarcinoma
Investigated by
Onconic Therapeutics Inc. · Jeil Pharmaceutical Co., Ltd. · Merck Sharp & Dohme LLC · Yonsei University

Trials 7 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT07570186 May → Jul 2026 overdue Onconic Therapeutics Inc. Not yet recruiting No outcome recorded
Phase 1 NCT04335604 Dec 2017 → Dec 2021 cancer Onconic Therapeutics Inc. Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT07364422 Feb 2026 overdue gastric cancer Onconic Therapeutics Inc. Not yet recruiting No outcome recorded
Phase 1/2 NCT05257993 Mar 2022 → Apr 2030 expected pancreatic ductal adenocarcinoma Onconic Therapeutics Inc. Recruiting No outcome recorded
Phase 23 trials
Phase 2 NCT07370818 Feb 2026 → Dec 2029 expected ovarian cancer Onconic Therapeutics Inc. Not yet recruiting No outcome recorded
Phase 2 NCT06502743 Sep 2024 → Dec 2027 expected endometrial carcinoma Yonsei University Recruiting No outcome recorded
Phase 2 NCT05475184 Aug 2022 → Nov 2024 overdue ovarian cancer Onconic Therapeutics Inc. Active not recruiting No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as Nesuparib ClinicalTrials.gov intervention name — accepted as the source's own label NCT06502743
Known as JPI-547 ClinicalTrials.gov intervention name — accepted as the source's own label NCT07370818
5

NCT05257993

NCT07364422

NCT07570186

NCT04335604

NCT05475184

Known as NOV140201 “A Study of NOV140201 (JPI-547) in Subject With Advanced Solid Tumors” NCT04335604
Action Inhibit “a Dual Inhibitor of PARP/TNK” NCT04335604
Modality Small molecule CHEMBL5095245
Route Oral “The investigational product is administered orally in a fasting state for 2 hours before and after meals at the same time (e.g., a certain time in the morning).” NCT05257993
Target PARP1 PARP1/2 and tankyrase 1/2 inhibitor” PMID 41514313 Dec 2025