Drugs / Vindesine
last change 10 days ago re-read 8 days ago

Vindesine

Small molecule

Developed for
leukemia · neuroblastoma · lymphoblastic lymphoma · lymphoma · peripheral T-cell lymphoma, not otherwise specified · diffuse large B-cell lymphoma · lung cancer · adult acute lymphoblastic leukemia
+18 more · high grade B-cell lymphoma · adult T-cell leukemia/lymphoma · anaplastic large cell lymphoma · B-cell acute lymphoblastic leukemia · Burkitt lymphoma · cervical cancer · classic Hodgkin lymphoma · high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement · lung neoplasm · lymphoid leukemia · mantle cell lymphoma · metastatic melanoma · neoplasm of mediastinum · non-Hodgkin lymphoma · thyroid gland carcinoma · childhood low-grade glioma · diffuse low-grade glioma, MAPK pathway–altered · early T cell progenitor acute lymphoblastic leukemia
Investigated by
German Society for Pediatric Oncology and Hematology GPOH gGmbH · The First Affiliated Hospital of Soochow University · Deutsche Krebshilfe e.V., Bonn (Germany) · French Innovative Leukemia Organisation · Gustave Roussy, Cancer Campus, Grand Paris · Johann Wolfgang Goethe University Hospital
+40 more · Lymphoma Study Association · The First Affiliated Hospital with Nanjing Medical University · Tianjin Medical University Cancer Institute and Hospital · Amgen · Children's Cancer Group, China · Children's Hospital Medical Center, Cincinnati · Children's Hospital of Soochow University · Chinese PLA General Hospital · Dermatologic Cooperative Oncology Group · European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma · European Organisation for Research and Treatment of Cancer - EORTC · Fondation ARC · GIMEMA Foundation · Goethe University · Han weidong · Hannover Medical School · Italian Association of Pediatric Hematology and Oncology · Janssen-Cilag International NV · Japan Clinical Oncology Group · Medical Research Council · Ministry of Health, Labour and Welfare, Japan · Nanfang Hospital, Southern Medical University · Nanjing Children's Hospital · National Cancer Institute (NCI) · Navy General Hospital, Beijing · Nicola Goekbuget · Qilu Hospital of Shandong University · Shandong Provincial Hospital · Shanghai Children's Medical Center · Shanxi Bethune Hospital · Tongji Hospital · University Hospital Muenster · University Hospital Schleswig-Holstein · University Hospital Southampton NHS Foundation Trust · University Hospital, Essen · University Hospital, Motol · West China Hospital · West China Second University Hospital · West Japan Thoracic Oncology Group · Xiangya Hospital of Central South University

Trials 41

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1/22 trials
Phase 1/2 NCT06176027 Oct 2024 → Sep 2028 expected peripheral T-cell lymphoma, not otherwise specified Navy General Hospital, Beijing Recruiting No outcome recorded
Phase 1/2 NCT04026269 Jul 2019 → Dec 2020 classic Hodgkin lymphoma Han weidong Unknown No outcome recorded
Phase 211 trials
Phase 2 NCT07159620 Sep 2025 → Sep 2028 expected adult T-cell leukemia/lymphoma The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 2 NCT07564453 Apr 2025 → Dec 2027 expected B-cell acute lymphoblastic leukemia The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 2 NCT06713057 Dec 2024 → Dec 2025 overdue thyroid gland carcinoma West China Hospital Not yet recruiting No outcome recorded
Phase 2 NCT06486337 Jul 2024 → Aug 2027 expected non-Hodgkin lymphoma The First Affiliated Hospital of Soochow University Recruiting No outcome recorded
Phase 2 NCT06433362 Jun 2024 → Jun 2025 peripheral T-cell lymphoma, not otherwise specified Tianjin Medical University Cancer Institute and Hospital Unknown No outcome recorded
Phase 2 NCT00136565 Jan 2006 → Apr 2011 peripheral T-cell lymphoma, not otherwise specified Lymphoma Study Association Completed No outcome recorded
Phase 2 NCT00128037 May 1999 → Feb 2006 lung neoplasm Japan Clinical Oncology Group Completed No outcome recorded
Phase 2 NCT00017225 May 1997 → Feb 2002 neuroblastoma German Society for Pediatric Oncology and Hematology GPOH gGmbH Completed No outcome recorded
Phase 2 NCT00869284 Oct 1994 → Jul 1999 lymphoma French Innovative Leukemia Organisation Completed No outcome recorded
Phase 2 NCT00002531 Jan 1993 → ? leukemia Johann Wolfgang Goethe University Hospital Unknown No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT07059156 Jun 2025 → Jun 2027 expected adult acute lymphoblastic leukemia Shanxi Bethune Hospital Recruiting No outcome recorded
Phase 317 trials · 1 met primary · 2 missed
Phase 3 NCT05097443 Apr 2021 → Dec 2023 high grade B-cell lymphoma, high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement, mantle cell lymphoma Shandong Provincial Hospital Unknown No outcome recorded
Phase 3 NCT04221035 Nov 2019 → Nov 2026 expected neuroblastoma Gustave Roussy, Cancer Campus, Grand Paris Recruiting No outcome recorded
Phase 3 NCT04043494 Aug 2019 → Apr 2030 expected lymphoblastic lymphoma University Hospital Muenster Recruiting No outcome recorded
Phase 3 NCT03018626 Jul 2017 → Jan 2020 diffuse large B-cell lymphoma Nanfang Hospital, Southern Medical University Unknown No outcome recorded
Phase 3 NCT02845882 Jan 2016 → Dec 2023 overdue lymphoblastic lymphoma Children's Cancer Group, China Active not recruiting No outcome recorded
Phase 3 NCT00920153 May 2008 → Mar 2016 lymphoma French Innovative Leukemia Organisation Terminated No outcome recorded
Phase 3 NCT00554164 Nov 2007 → Mar 2017 high grade B-cell lymphoma University Hospital, Essen Completed Missed primary
Phase 3 NCT00410631 Oct 2004 → Dec 2010 neuroblastoma German Society for Pediatric Oncology and Hematology GPOH gGmbH Unknown No outcome recorded
Phase 3 NCT00764907 Nov 2002 → Oct 2007 leukemia University Hospital, Motol Unknown No outcome recorded
Phase 3 NCT00135499 Oct 2001 → Apr 2010 diffuse large B-cell lymphoma Lymphoma Study Association Terminated No outcome recorded Stop: Enrollment
Phase 44 trials
Phase 4 NCT00199017 Apr 2004 → Mar 2009 lymphoblastic lymphoma Johann Wolfgang Goethe University Hospital Completed No outcome recorded
Phase 4 NCT00199082 Jul 2002 → Jun 2010 Burkitt lymphoma, anaplastic large cell lymphoma, lymphoblastic lymphoma, neoplasm of mediastinum Nicola Goekbuget Completed No outcome recorded
Phase 4 NCT00226473 Sep 2001 → Sep 2005 metastatic melanoma Dermatologic Cooperative Oncology Group Unknown No outcome recorded
Phase 4 NCT00199056 Oct 1999 → Nov 2003 adult acute lymphoblastic leukemia Goethe University Completed No outcome recorded
Phase not applicable6 trials
— NCT05896813 Mar 2023 → Jan 2025 peripheral T-cell lymphoma, not otherwise specified The First Affiliated Hospital with Nanjing Medical University Unknown No outcome recorded
— NCT05777369 Mar → Aug 2023 diffuse large B-cell lymphoma The First Affiliated Hospital with Nanjing Medical University Unknown No outcome recorded
— NCT01156883 Apr 2010 → Oct 2017 leukemia GIMEMA Foundation Completed No outcome recorded
— NCT00689845 Jun 2007 → ? lymphoma University Hospital Southampton NHS Foundation Trust Unknown No outcome recorded
— NCT00526318 Jan 2007 → Dec 2016 neuroblastoma German Society for Pediatric Oncology and Hematology GPOH gGmbH Unknown No outcome recorded
— NCT00317408 Apr 2004 → Feb 2014 lymphoma European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma Unknown No outcome recorded
Comparator or background therapy36 trials
Phase 1 NCT00002887 Background Jul 1995 → ? lung cancer Ottawa Regional Cancer Centre Unknown No outcome recorded
Phase 1/2 NCT06739265 Background Sep 2024 → Sep 2026 overdue peripheral T-cell lymphoma, not otherwise specified Peking Union Medical College Hospital Recruiting No outcome recorded
Phase 1/2 NCT02987244 Background Mar 2016 → Mar 2020 T-cell non-Hodgkin lymphoma Peking Union Medical College Hospital Unknown No outcome recorded
Phase 2 NCT07680933 Background Mar 2026 → Jun 2027 expected diffuse large B-cell lymphoma The Affiliated Hospital of Xuzhou Medical University Recruiting No outcome recorded
Phase 2 NCT06918015 Background May 2025 → May 2028 expected follicular lymphoma Zhejiang Cancer Hospital Not yet recruiting No outcome recorded

Evidence & citations 14 cited values

Every value below carries the sentence it was read from. 78 sources stand behind the page.

FieldValueCited text
Known as vindesine “Immunochemotherapy in Primary Central Nervous System Lymphoma With Rituximab, HD-MTX, HD-Ara C, Cyclophosphamide, Ifosfamide, Vincristine, Vindesine, Temozolomide and DepoCyte...” NCT01458730 ↗
75

“Patients with a persistently positive interim-PET scan assigned to arm B2 will receive six blocks of the B-ALL protocol (rituximab, methotrexate, ifosfamide, etoposide,...” NCT00554164 ↗

“Patients were treated by Azacytidine(75 mg/m2 on days 1-7) plus CAOLD regimen (cyclophosphamide 400mg/m2 qd d1; cytarabine 30mg/m2 qd d1-d4; vindesine 2mg/m2 qd d1;...” NCT06176027 ↗

“Used drugs are rituximab,cyclophosphamide, prednisone, dexamethasone, vincristine, methotrexate, iphosphamide, teniposide, etoposide, dexamethasone, cytarabine,adriamycin,...” NCT01290120 ↗

“cyclophosphamide, anthracene nucleus chemotherapeutics(doxorubicin,liposomal doxorubicin, etc.), vinca alkaloids(vincristine, vindesine, etc.),and glucocorticoid...” NCT05498259 ↗

“The induction therapy is a combination of Blinatumomab(Blina), Vindesine(VDS), Cyclophosphamide(CTX) and Dexamethasone(DXM).” NCT06742515 ↗

“The CHOP include cyclophosphamide, doxorubicin/Epirubicin/liposomal doxorubicin, vincristine/Vindesine, and prednison.” NCT05933967 ↗

“4. Vindesine: 3 mg/m2 (maximum dose 4 mg) intravenously on days 1 of every cycle;” NCT06918015 ↗

“(or liposomal doxorubicin 35mg/m2 d1), vindesine 4mg d1, prednisone: 100mg, d1-5.” NCT06674096 ↗

“Vindesine: 3 mg/m²/day (max 4 mg), administered on days 1, 8, 15, 22.” NCT07059156 ↗

“CHOP regimen(Cyclophosphamide,Vindesine,Epirubicin,Prednisone)” NCT03631862 ↗

Show 65 more sources

Known as COMPOUND 112531 ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Known as DAVA “vindesine (DAVA) IV on day 50” NCT00003728 ↗
Known as Eldisine ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Known as Fildesin ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Known as LY-099094 ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Known as NSC-245467 ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Known as VDS “The induction therapy is a combination of Blinatumomab(Blina), Vindesine(VDS), Cyclophosphamide(CTX) and Dexamethasone(DXM).” NCT06742515 ↗
Known as Vindesina ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Known as Vindesine Sulfate “Vindesine Sulfate for Injection 4mg d1,8 iv” NCT04026269 ↗
1

“Drug: Vindesine Sulfate” NCT03206671 ↗

Known as Vindesine sulfate salt ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Known as Vindesine sulphate ChEMBL registry synonym — accepted as the source's own label CHEMBL238071 ↗
Modality Small molecule — CHEMBL238071 ↗
Route Intravenous “vindesine IV and daunorubicin IV on days 1, 8, and 15” NCT00002532 ↗