Combination Chemotherapy Followed By Stem Cell Transplant in Treating Young Patients With Progressive or Relapsed Anaplastic Large Cell Lymphoma
Summary
RATIONALE: Giving combination chemotherapy and total-body irradiation before a peripheral stem cell transplant that uses the patient's or a donor's stem cells, helps stop both the growth of cancer cells and the patient's immune system from rejecting the stem cells. When the stem cells are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Giving combination chemotherapy and total-body irradiation followed by a stem cell transplant may be an effective treatment for anaplastic large cell lymphoma. PURPOSE: This clinical trial is studying how well combination chemotherapy followed by stem cell transplant works in treating young patients with progressive or relapsed anaplastic large cell lymphoma.
Timeline
- Start
- 2004-04
- Primary completion
- 2014-02
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Busulfan | Small molecule | — | Oral |
| Subject | Carboplatin | Small molecule | — | Intravenous |
| Subject | Cytarabine | Small molecule | — | Intrathecal |
| Subject | Dexamethasone | Small molecule | — | Oral |
| Subject | Etoposide | Small molecule | — | Intravenous |
| Subject | Idarubicin | Small molecule | — | Intravenous |
| Subject | Ifosfamide | Small molecule | — | Intravenous |
| Subject | Lomustine | Small molecule | — | Oral |
| Subject | Melphalan | Small molecule | — | Intravenous |
| Subject | Methotrexate | Small molecule | — | Intrathecal |
| Subject | Mitoxantrone | Small molecule | — | Intravenous |
| Subject | Prednisolone | Other / unclassified | — | Intrathecal |
| Subject | Thiotepa | Other / unclassified | — | Intravenous |
| Subject | Vinblastine | Small molecule | — | Intravenous |
| Subject | Vindesine | Small molecule | — | Intravenous |
| Subject | carmustine | Small molecule | — | Intravenous |
| Background | ANTILYMPHOCYTE IMMUNOGLOBULIN (HORSE) | Protein / enzyme biologic | — | Intravenous |
| Background | Cyclosporine | Peptide | — | Intravenous |
| Background | Leucovorin | Small molecule | — | Intravenous |