Bleomycin

also known as Bleomycin Sulfate · NSC-125066 · BLEO · Bleomicina · Bleomicine · Bleomycin (B) · Bleomycin hydrochloride · Bleomycin PHC 15 e.

Developed for: lymphoma · Hodgkins lymphoma · extragonadal germ cell tumor · Kaposi's sarcoma · testicular germ cell tumor · classic Hodgkin lymphoma · head and neck cancer · childhood germ cell tumor
+59 more
· teratoma · hemangioma · central nervous system neoplasm · cervical cancer · diffuse large B-cell lymphoma · Hodgkin's lymphoma, lymphocytic depletion · Hodgkin's lymphoma, mixed cellularity · metastatic malignant neoplasm · nodular lymphocyte predominant Hodgkin lymphoma · nodular sclerosis classical Hodgkin lymphoma · non-Hodgkin lymphoma · ovarian cancer · peripheral T-cell lymphoma, not otherwise specified · testicular seminoma · vulva cancer · breast cancer · cancer · central nervous system germinoma · childhood testicular germ cell tumor · common wart · cutaneous melanoma · extragonadal nonseminomatous germ cell tumor · female reproductive organ cancer · gastric cancer · germ cell tumor · head and neck squamous cell carcinoma · keloid · large B-cell lymphoma · liver cancer · lymphatic malformation · malignant mixed neoplasm · malignant pancreatic neoplasm · mediastinal cancer · metastasis from malignant tumor of colon · metastatic carcinoma · metastatic malignant neoplasm in the brain · nongerminomatous germ cell tumor · ovarian carcinoma · ovarian embryonal carcinoma · ovarian granulosa cell tumor · ovarian gynandroblastoma · ovarian Sertoli-Leydig cell tumor · ovarian yolk sac tumor · pediatric ovarian germ cell tumor · pericardial effusion · plantar wart · plasma cell neoplasm · skin cancer · skin neoplasm · testicular embryonal carcinoma · testicular non-seminomatous germ cell tumor · urinary bladder cancer · urothelial carcinoma · vascular malformation · vulval Paget disease · capillary malformation · malignant germ cell tumor of ovary · neoplasm of testis · ovarian sex cord-stromal tumor
Investigated by: National Cancer Institute (NCI) · European Organisation for Research and Treatment of Cancer - EORTC · Children's Oncology Group · National Institute of Allergy and Infectious Diseases (NIAID) · Eastern Cooperative Oncology Group · Fondazione Italiana Linfomi - ETS
+122 more
· Institute of Oncology Ljubljana · Lymphoma Study Association · SWOG Cancer Research Network · Children's Cancer and Leukaemia Group · Inovio Pharmaceuticals · Lymphoma Trials Office · M.D. Anderson Cancer Center · Medical Research Council · Stanford University · University of Cologne · Cancer Research UK · Copenhagen University Hospital at Herlev · Rigshospitalet, Denmark · Sequus Pharmaceuticals · Alliance for Clinical Trials in Oncology · Amgen · Cambridge University Hospitals NHS Foundation Trust · Cancer and Leukemia Group B · Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte · Children's Cancer Group · French Innovative Leukemia Organisation · Herlev Hospital · King Edward Medical University · Memorial Sloan Kettering Cancer Center · Ministry of Health, Labour and Welfare, Japan · PCI Biotech AS · Seagen Inc. · St. Jude Children's Research Hospital · UNICANCER · University Medical Centre Ljubljana · University of Ljubljana · Uppsala University Hospital · Zealand University Hospital · AIDS Malignancy Consortium · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Australasian Leukaemia and Lymphoma Group · Australian and New Zealand Urogenital and Prostate Cancer Trials Group · Barbara Ensoli, MD, PhD · Baylor College of Medicine · Bristol-Myers Squibb · Cancer Institute WIA · Cancer Research UK & UCL Cancer Trials Centre · Cancer Trials Ireland · Case Comprehensive Cancer Center · Centre Leon Berard · Centro di Riferimento Oncologico - Aviano · City of Hope Medical Center · Clinica Dermatologica Arbache ltda · Consorzio Mario Negri Sud · Dana-Farber Cancer Institute · Deutsche AIDS Gesellschaft e.V. · ECOG-ACRIN Cancer Research Group · Fondation ARC · Fondazione Policlinico Universitario Agostino Gemelli IRCCS · GITIL (GRUPPO ITALIANO TERAPIE INNOVATIVE NEI LINFOMI) · GOG Foundation · Genentech, Inc. · Glostrup University Hospital, Copenhagen · Grup per l'Estudi dels Limfomes de Catalunya i Balears · Gustave Roussy, Cancer Campus, Grand Paris · H. Lee Moffitt Cancer Center and Research Institute · Harlachinger Krebshilfe e.V. · Haruhiko Fukuda · Haukeland University Hospital · Heinrich-Heine University, Duesseldorf · Helwan University · Hospital JP Garrahan · IRCCS Azienda Ospedaliero-Universitaria di Bologna · Ichor Medical Systems Incorporated · Institute of Cancer Research, United Kingdom · Janssen-Cilag International NV · Japan Clinical Oncology Group · Jinnah Postgraduate Medical Centre · Julie Gehl · all 128 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansion	US (FDA)	BLENOXANE	—	1996-02-20	fda.gov ↗
Approved	US (FDA)	BLENOXANE	—	1973-07-31	fda.gov ↗

Trials 137 · started per year

today

US approved 1973

1972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 18 trials
Phase 1	NCT04139070	Jun 2020 → Jan 2021	gastric cancer	Zealand University Hospital	Unknown	No outcome recorded
Phase 1	NCT01872923	Jan → Oct 2012	skin cancer	PCI Biotech AS	Completed	No outcome recorded
Phase 1	NCT01322100	Apr 2011 → Jul 2013	metastatic malignant neoplasm in the brain	Copenhagen University Hospital at Herlev	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT00031902	Oct 2001 → ?	lymphoma	Lymphoma Trials Office	Unknown	No outcome recorded
Phase 1	NCT00027521	Dec 2000 → ?	malignant pancreatic neoplasm	Ichor Medical Systems Incorporated	Withdrawn	No outcome recorded
Phase 1	NCT00006035	Jun 2000 → ?	cutaneous melanoma	H. Lee Moffitt Cancer Center and Research Institute	Unknown	No outcome recorded
Phase 1	NCT00000987	? → Apr 1992	HIV infectious disease, Kaposi's sarcoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 1	NCT00000954	? → Sep 1996	HIV infectious disease, Kaposi's sarcoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 1/22 trials
Phase 1/2	NCT02291133	Jun 2014 → Sep 2019	liver cancer	Masa Bosnjak	Completed	No outcome recorded
Phase 1/2	NCT00032149	Oct 2001 → ?	lymphoma	Lymphoma Trials Office	Unknown	No outcome recorded
Phase 254 trials · 2 met primary · 2 missed
Phase 2	NCT07579962	Sep 2026 → Jun 2031 expected	vascular malformation	Institute of Oncology Ljubljana	Recruiting	No outcome recorded
Phase 2	NCT06144736	Aug 2023 → Aug 2026 overdue	testicular seminoma	Heinrich-Heine University, Duesseldorf	Recruiting	No outcome recorded
Phase 2	NCT06715592	May 2023 → Mar 2025 overdue	vulval Paget disease	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	Active not recruiting	No outcome recorded
Phase 2	NCT06437158	Mar 2023 → Dec 2025 overdue	lymphatic malformation	West China Hospital	Recruiting	No outcome recorded
Phase 2	NCT05395962	Apr 2022 → Apr 2025 overdue	vulva cancer	IRCCS Azienda Ospedaliero-Universitaria di Bologna	Recruiting	No outcome recorded
Phase 2	NCT05008224	Oct 2021 → Oct 2023	classic Hodgkin lymphoma	Merck Sharp & Dohme LLC	Completed	No outcome recorded
Phase 2	NCT05023408	Jan → Jun 2021	common wart	Jinnah Postgraduate Medical Centre	Completed	No outcome recorded
Phase 2	NCT04760327	Jul 2020 → Dec 2025 overdue	female reproductive organ cancer	Institute of Oncology Ljubljana	Recruiting	No outcome recorded
Phase 2	NCT03755804	Dec 2018 → Jan 2027 expected	classic Hodgkin lymphoma	St. Jude Children's Research Hospital	Active not recruiting	No outcome recorded
Phase 2	NCT03712202	Nov 2018 → Dec 2024 overdue	Hodgkin's lymphoma, lymphocytic depletion, Hodgkin's lymphoma, mixed cellularity, nodular sclerosis classical Hodgkin lymphoma	City of Hope Medical Center	Active not recruiting	No outcome recorded
Phase 2	NCT02788201	Mar 2017 → Oct 2019	urinary bladder cancer, urothelial carcinoma	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 2	NCT03040180	Jan 2017 → Jun 2019	chemotherapy-induced toxicity	Zealand University Hospital	Unknown	No outcome recorded
Phase 2	NCT02104986	May 2014 → Oct 2021	extragonadal nonseminomatous germ cell tumor	Centre Leon Berard	Completed	No outcome recorded
Phase 2	NCT02549742	Feb 2014 → Sep 2019	head and neck cancer	Rigshospitalet, Denmark	Unknown	No outcome recorded
Phase 2	NCT02352259	Sep 2013 → Oct 2018	metastasis from malignant tumor of colon	Institute of Oncology Ljubljana	Completed	No outcome recorded
Phase 2	NCT01390584	May 2013 → Apr 2015	lymphoma	ECOG-ACRIN Cancer Research Group	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT02782754	Jan 2013 → Dec 2017	central nervous system germinoma	Samsung Medical Center	Unknown	No outcome recorded
Phase 2	NCT01858922	Dec 2012 → Aug 2019	Hodgkins lymphoma	Baylor College of Medicine	Completed	No outcome recorded
Phase 2	NCT01606566	Apr 2012 → Aug 2015	head and neck squamous cell carcinoma	PCI Biotech AS	Terminated	No outcome recorded Stop: Business
Phase 2	NCT02247869	Feb 2012 → Jun 2015	Hodgkins lymphoma	Fondazione Italiana Linfomi - ETS	Completed	No outcome recorded
Phase 2	NCT01479946	Oct 2011 → Dec 2014	breast cancer, skin neoplasm	Uppsala University Hospital	Withdrawn	No outcome recorded
Phase 2	NCT01523847	Nov 2010 → Oct 2013	Hodgkins lymphoma	Fondazione Italiana Linfomi - ETS	Completed	No outcome recorded
Phase 2	NCT01118026	Sep 2010 → Sep 2020	lymphoma	Alliance for Clinical Trials in Oncology	Completed	No outcome recorded
Phase 2	NCT01132807	May 2010 → Feb 2016	lymphoma	Alliance for Clinical Trials in Oncology	Completed	No outcome recorded
Phase 2	NCT01042522	Feb 2010 → Jun 2020	ovarian Sertoli-Leydig cell tumor, ovarian granulosa cell tumor, ovarian gynandroblastoma	GOG Foundation	Unknown	Missed primary
Phase 2	NCT00918593	Dec 2009 → Aug 2013	—	Copenhagen University Hospital at Herlev	Withdrawn	No outcome recorded Stop: Enrollment
Phase 2	NCT00983944	Sep 2009 → Apr 2011	large B-cell lymphoma	Ohio State University Comprehensive Cancer Center	Withdrawn	No outcome recorded Stop: Enrollment
Phase 2	NCT00822120	Jul 2009 → Apr 2016	lymphoma	SWOG Cancer Research Network	Completed	No outcome recorded
Phase 2	NCT00846742	Jun 2009 → Jan 2019 overdue	Hodgkins lymphoma	St. Jude Children's Research Hospital	Active not recruiting	Met primary
Phase 2	NCT00795613	Jun 2008 → Nov 2014	Hodgkins lymphoma	Ospedale Santa Croce-Carle Cuneo	Unknown	No outcome recorded
Phase 2	NCT01067690	Jun 2008 → Oct 2015	Kaposi's sarcoma	Barbara Ensoli, MD, PhD	Completed	No outcome recorded
Phase 2	NCT00369681	May 2006 → Oct 2014	lymphoma	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	Completed	No outcome recorded
Phase 2	NCT00136565	Jan 2006 → Apr 2011	peripheral T-cell lymphoma, not otherwise specified	Lymphoma Study Association	Completed	No outcome recorded
Phase 2	NCT00301782	Jun 2005 → Jun 2010	extragonadal germ cell tumor, teratoma, testicular germ cell tumor	Medical Research Council	Completed	Met primary
Phase 2	NCT00453232	Aug 2004 → Dec 2008	extragonadal germ cell tumor, teratoma, testicular germ cell tumor	Cambridge University Hospitals NHS Foundation Trust	Completed	No outcome recorded
Phase 2	NCT01468740	Mar 2004 → Feb 2012	Hodgkins lymphoma	Harlachinger Krebshilfe e.V.	Unknown	No outcome recorded
Phase 2	NCT00284271	Jan 2004 → Dec 2005	Hodgkins lymphoma	University of Cologne	Completed	No outcome recorded
Phase 2	NCT00225173	Oct 2001 → Sep 2005	Hodgkins lymphoma	Stanford University	Terminated	No outcome recorded
Phase 2	NCT00026208	Jun 2001 → Apr 2013	Hodgkins lymphoma	Stanford University	Completed	No outcome recorded
Phase 2	NCT00006916	Jun 2001 → Dec 2005	central nervous system neoplasm	Radiation Therapy Oncology Group	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT00504504	Mar 2001 → Mar 2012	lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 2	NCT00003811	Apr 2000 → Oct 2004	childhood germ cell tumor, extragonadal germ cell tumor, ovarian cancer, poisoning	Children's Oncology Group	Completed	Missed primary
Phase 2	NCT00025064	Jan 2000 → ?	lymphoma	Children's Cancer and Leukaemia Group	Unknown	No outcome recorded
Phase 2	NCT00004010	Oct 1999 → Oct 2003	lymphoma	Children's Oncology Group	Completed	No outcome recorded
Phase 2	NCT00003110	Jul 1997 → Aug 2001	lymphoma	Case Comprehensive Cancer Center	Completed	No outcome recorded
Phase 2	NCT00003262	May 1997 → ?	lymphoma	Centro di Riferimento Oncologico - Aviano	Unknown	No outcome recorded
Phase 2	NCT00592111	Mar 1996 → Feb 1999	Hodgkins lymphoma	Memorial Sloan Kettering Cancer Center	Completed	No outcome recorded
Phase 2	NCT00002657	May 1995 → Nov 2003	plasma cell neoplasm	SWOG Cancer Research Network	Completed	No outcome recorded
Phase 2	NCT00002714	Apr 1995 → Sep 2001	lymphoma	Stanford University	Completed	No outcome recorded
Phase 2	NCT00002571	Jun 1994 → Nov 2003	lymphoma	SWOG Cancer Research Network	Completed	No outcome recorded
Phase 2	NCT00002524	Jun 1993 → Oct 2005	lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 2	NCT00002715	Apr 1989 → Jan 2007	lymphoma	Stanford University	Completed	No outcome recorded
Phase 2	NCT00000626	? → Feb 1999	HIV infectious disease, Hodgkins lymphoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 2	NCT00001059	? → Aug 1998	HIV infectious disease, Kaposi's sarcoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded

Phase 2/31 trial · 1 missed
Phase 2/3	NCT00784537	Sep 2008 → Jan 2015	Hodgkins lymphoma	Fondazione Italiana Linfomi - ETS	Completed	Missed primary
Phase 350 trials · 2 met primary · 8 missed
Phase 3	NCT05675410	May 2023 → Apr 2031 expected	Hodgkins lymphoma	National Cancer Institute (NCI)	Recruiting	No outcome recorded
Phase 3	NCT04638790	Feb 2020 → Dec 2026 expected	classic Hodgkin lymphoma	State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia	Recruiting	No outcome recorded
Phase 3	NCT03159897	Aug 2017 → Nov 2021	classic Hodgkin lymphoma	Fondazione Italiana Linfomi - ETS	Completed	No outcome recorded
Phase 3	NCT03018626	Jul 2017 → Jan 2020	diffuse large B-cell lymphoma	Nanfang Hospital, Southern Medical University	Unknown	No outcome recorded
Phase 3	NCT02341989	Apr 2015 → May 2027 expected	testicular seminoma	St. Olavs Hospital	Active not recruiting	No outcome recorded
Phase 3	NCT02582697	Feb 2014 → Dec 2029 expected	germ cell tumor	University of Sydney	Recruiting	No outcome recorded
Phase 3	NCT01435018	Oct 2013 → Mar 2018	HIV infectious disease	Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections	Completed	Missed primary
Phase 3	NCT01652261	May 2013 → Oct 2014	Hodgkins lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	Withdrawn	No outcome recorded Stop: Enrollment
Phase 3	NCT01726374	Feb 2010 → Aug 2016	testicular non-seminomatous germ cell tumor	Institute of Cancer Research, United Kingdom	Completed	Met primary
Phase 3	NCT01026220	Dec 2009 → Mar 2012	nodular lymphocyte predominant Hodgkin lymphoma	Children's Oncology Group	Completed	No outcome recorded
Phase 3	NCT00678327	Aug 2008 → Jan 2016	lymphoma	University College, London	Completed	No outcome recorded
Phase 3	NCT00920153	May 2008 → Mar 2016	lymphoma	French Innovative Leukemia Organisation	Terminated	No outcome recorded
Phase 3	NCT00515554	May 2008 → Jul 2019	Hodgkins lymphoma	University of Cologne	Completed	Mixed
Phase 3	NCT00433433	Oct 2006 → Dec 2011	lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	Unknown	Missed primary
Phase 3	NCT00274950	May 2005 → May 2010	childhood germ cell tumor, extragonadal germ cell tumor, ovarian carcinoma	Children's Cancer and Leukaemia Group	Unknown	No outcome recorded
Phase 3	NCT00198328	Nov 2004 → Jun 2007	head and neck cancer	Inovio Pharmaceuticals	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00198315	Jun 2004 → Jun 2007	head and neck cancer	Inovio Pharmaceuticals	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00104676	Nov 2003 → Mar 2012	extragonadal germ cell tumor, teratoma, testicular germ cell tumor	UNICANCER	Completed	Missed primary
Phase 3	NCT00053352	Nov 2003 → Oct 2013	childhood testicular germ cell tumor, ovarian embryonal carcinoma, ovarian yolk sac tumor, pediatric ovarian germ cell tumor +2	Children's Oncology Group	Completed	No outcome recorded
Phase 3	NCT00324298	Jul 2003 → Mar 2011	chemotherapy-induced toxicity, testicular germ cell tumor	Queen Mary University of London	Completed	No outcome recorded
Phase 3	NCT00025259	Sep 2002 → Aug 2012	Hodgkin's lymphoma, lymphocytic depletion, Hodgkin's lymphoma, mixed cellularity, nodular lymphocyte predominant Hodgkin lymphoma, nodular sclerosis classical Hodgkin lymphoma	Children's Oncology Group	Completed	No outcome recorded
Phase 3	NCT00049595	Aug 2002 → Jan 2010	lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	Completed	Missed primary
Phase 3	NCT00190528	Feb 2002 → Dec 2004	cervical cancer	Haruhiko Fukuda	Terminated	No outcome recorded
Phase 3	NCT00135499	Oct 2001 → Apr 2010	diffuse large B-cell lymphoma	Lymphoma Study Association	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00041210	Oct 2001 → ?	lymphoma	Mount Vernon Cancer Centre at Mount Vernon Hospital	Unknown	No outcome recorded
Phase 3	NCT00005090	Apr 2000 → May 2005	lymphoma	SWOG Cancer Research Network	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00132613	Aug 1999 → Nov 2006	pericardial effusion	Japan Clinical Oncology Group	Completed	No outcome recorded
Phase 3	NCT00003389	Jun 1999 → Sep 2011	lymphoma	Eastern Cooperative Oncology Group	Completed	Missed primary
Phase 3	NCT00003941	Apr 1999 → Jun 2007	mediastinal cancer, metastatic malignant neoplasm, testicular germ cell tumor	European Organisation for Research and Treatment of Cancer - EORTC	Completed	Missed primary
Phase 3	NCT00265031	Jan 1999 → ?	Hodgkins lymphoma	University of Cologne	Completed	Mixed
Phase 3	NCT00005584	Oct 1998 → May 2004 overdue	lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	Active not recruiting	Mixed
Phase 3	NCT00003421	Jun 1998 → Nov 2005	lymphoma	Medical Research Council	Completed	Missed primary
Phase 3	NCT00265018	May 1998 → Jan 2003	Hodgkins lymphoma	University of Cologne	Completed	No outcome recorded
Phase 3	NCT00005867	Jan 1998 → Aug 2007	lymphoma	Lymphoma Trials Office	Completed	No outcome recorded
Phase 3	NCT00003209	Dec 1997 → Dec 1999	cervical cancer	European Organisation for Research and Treatment of Cancer - EORTC	Completed	No outcome recorded
Phase 3	NCT00002872	Jan 1997 → Feb 2003	metastatic malignant neoplasm	Eastern Cooperative Oncology Group	Completed	No outcome recorded
Phase 3	NCT00002987	Jan 1997 → ?	lymphoma	Medical Research Council	Unknown	No outcome recorded
Phase 3	NCT00002827	Oct 1996 → Oct 2004	chemotherapy-induced toxicity, lymphoma	Children's Oncology Group	Completed	No outcome recorded
Phase 3	NCT00002835	Oct 1995 → Feb 2004	lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 3	NCT00970385	Jan 1995 → Dec 2002	peripheral T-cell lymphoma, not otherwise specified	University Hospital, Grenoble	Completed	No outcome recorded
Phase 3	NCT00002596	Sep 1994 → Jul 2006	childhood germ cell tumor, extragonadal germ cell tumor, testicular germ cell tumor	Memorial Sloan Kettering Cancer Center	Completed	Missed primary
Phase 3	NCT00003815	Jun 1994 → ?	lymphoma	Scotland and Newcastle Lymphoma Group	Unknown	No outcome recorded
Phase 3	NCT00002565	May 1994 → Feb 2007	lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 3	NCT00379041	Sep 1993 → Oct 1998 overdue	lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	Active not recruiting	Met primary
Phase 3	NCT00002476	Jan 1990 → Jan 2010	head and neck cancer	Cancer Research UK	Completed	Mixed
Phase 3	NCT00002462	Sep 1989 → May 2000 overdue	lymphoma	European Organisation for Research and Treatment of Cancer - EORTC	Active not recruiting	No outcome recorded
Phase 3	NCT00002105	—	HIV infectious disease, Kaposi's sarcoma	Sequus Pharmaceuticals	Completed	No outcome recorded
Phase 3	NCT00002093	—	HIV infectious disease, Kaposi's sarcoma	Nexstar Pharmaceuticals	Completed	No outcome recorded
Phase 3	NCT00002318	—	HIV infectious disease, Kaposi's sarcoma	Sequus Pharmaceuticals	Unknown	No outcome recorded
Phase 3	NCT00000658	? → Feb 1996	HIV infectious disease, non-Hodgkin lymphoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded

Phase 47 trials
Phase 4	NCT07197541	Oct 2025 → Nov 2026 expected	plantar wart	Second Affiliated Hospital, School of Medicine, Zhejiang University	Active not recruiting	No outcome recorded
Phase 4	NCT06647342	Oct 2024 → Mar 2027 expected	chemotherapy-induced toxicity, malignant mixed neoplasm, metastatic carcinoma, pulmonary fibrosis	Julie Gehl	Recruiting	No outcome recorded
Phase 4	NCT04046679	Aug 2019 → Aug 2020	—	Clinica Dermatologica Arbache ltda	Unknown	No outcome recorded
Phase 4	NCT03500133	Oct 2017 → Oct 2027 expected	Hodgkins lymphoma	Hospital JP Garrahan	Recruiting	No outcome recorded
Phase 4	NCT00198276	Feb 2004 → Sep 2008	cancer	Inovio Pharmaceuticals	Completed	No outcome recorded
Phase 4	NCT00198263	Jan 2004 → Sep 2008	head and neck cancer	Inovio Pharmaceuticals	Completed	No outcome recorded
Phase 4	NCT00188149	May 2000 → Dec 2007	Hodgkins lymphoma	University Hospital Carl Gustav Carus	Unknown	No outcome recorded
Phase not applicable15 trials · 1 missed
—	NCT07201766	Dec 2025 → Feb 2026 overdue	keloid	King Edward Medical University	Not yet recruiting	No outcome recorded
—	NCT07104526	Jan 2024 → Jan 2025	hemangioma	Wuhan Integrated Traditional Chinese and Western Medicine Hospital	Completed	No outcome recorded
—	NCT05705687	May 2023 → Feb 2031 expected	nongerminomatous germ cell tumor	Gustave Roussy, Cancer Campus, Grand Paris	Recruiting	No outcome recorded
—	NCT07171827	Mar 2023 → Feb 2025	classic Hodgkin lymphoma	Helwan University	Completed	No outcome recorded
—	NCT06080724	Mar → Dec 2021	hemangioma	King Edward Medical University	Completed	No outcome recorded
—	NCT05916690	Mar 2021 → Dec 2024	vulva cancer	Institute of Oncology Ljubljana	Unknown	No outcome recorded
—	NCT02800447	Jun 2016 → Dec 2018	Hodgkins lymphoma	Lee's Pharmaceutical Limited	Unknown	No outcome recorded
—	NCT05327309	May 2015 → May 2017	hemangioma	Shaheed Zulfiqar Ali Bhutto Medical University	Completed	No outcome recorded
—	NCT01578967	Apr 2012 → Aug 2016	Hodgkins lymphoma	UNC Lineberger Comprehensive Cancer Center	Completed	No outcome recorded
—	NCT01304849	Jan 2011 → Sep 2013	Hodgkins lymphoma	Cancer Institute WIA	Completed	Missed primary
—	NCT00901303	Oct 2008 → Jun 2010	Hodgkins lymphoma	Weill Medical College of Cornell University	Terminated	No outcome recorded Stop: Enrollment
—	NCT00689845	Jun 2007 → ?	lymphoma	University Hospital Southampton NHS Foundation Trust	Unknown	No outcome recorded
—	NCT00276718	Apr 1989 → ?	central nervous system neoplasm, childhood germ cell tumor, extragonadal germ cell tumor, ovarian cancer	Children's Cancer and Leukaemia Group	Unknown	No outcome recorded
—	NCT00000703	? → Mar 1990	HIV infectious disease, non-Hodgkin lymphoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
—	NCT00416377	—	lymphoma	Children's Cancer and Leukaemia Group	Unknown	No outcome recorded

Comparator or background therapy51 trials
Phase 1	NCT01060904 Background	Jan 2010 → Sep 2012	Hodgkins lymphoma	Seagen Inc.	Completed	No outcome recorded
Phase 1	NCT00993512 Background	Aug 2009 → May 2011	head and neck neoplasm, skin neoplasm	PCI Biotech AS	Completed	No outcome recorded
Phase 1	NCT00000689 Background	? → Mar 1991	HIV infectious disease, non-Hodgkin lymphoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 1	NCT00000681 Background	? → Oct 1993	HIV infectious disease, Kaposi's sarcoma	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 1/2	NCT03033914 Background	Jan 2017 → Jan 2027 expected	classic Hodgkin lymphoma	Memorial Sloan Kettering Cancer Center	Active not recruiting	No outcome recorded
Phase 2	NCT07320001 Comparator	Jan → Jul 2026 overdue	lymphatic malformation	Basharat Hussain	Not yet recruiting	No outcome recorded
Phase 2	NCT07847190 Background	Oct 2024 → Oct 2028 expected	malignant germ cell tumor	Blokhin's Russian Cancer Research Center	Recruiting	No outcome recorded
Phase 2	NCT03830385 Background	Feb 2019 → Feb 2021	head and neck squamous cell carcinoma	Sun Yat-sen University	Unknown	No outcome recorded
Phase 2	NCT03407144 Background	Apr 2018 → Feb 2027 expected	classic Hodgkin lymphoma	Merck Sharp & Dohme LLC	Active not recruiting	No outcome recorded
Phase 2	NCT03527628 Background	Jan 2018 → Jan 2021	classic Hodgkin lymphoma	King Abdullah International Medical Research Center	Unknown	No outcome recorded
Phase 2	NCT02883023 Comparator	Nov 2016 → Jan 2018	capillary malformation, vascular malformation	Sophie Horbach	Unknown	No outcome recorded
Phase 2	NCT02298283 Background	Apr 2015 → Jul 2020	Hodgkins lymphoma	The Lymphoma Academic Research Organisation	Completed	No outcome recorded
Phase 2	NCT02292979 Comparator	Mar 2015 → Dec 2016	Hodgkins lymphoma	The Lymphoma Academic Research Organisation	Completed	Met primary
Phase 2	NCT02784054 Background	Apr 2014 → Mar 2021	central nervous system nongerminomatous germ cell tumor	Samsung Medical Center	Unknown	No outcome recorded
Phase 2	NCT01941901 Comparator	Sep 2013 → Sep 2016	—	Herlev Hospital	Completed	No outcome recorded
Phase 2	NCT01873326 Comparator	Jun 2013 → Jun 2027 expected	germ cell tumor	Memorial Sloan Kettering Cancer Center	Active not recruiting	No outcome recorded
Phase 2	NCT02275598 Background	Apr → Nov 2013	Hodgkins lymphoma	University of Modena and Reggio Emilia	Unknown	No outcome recorded
Phase 2	NCT00797472 Comparator	Jul 2011 → Apr 2014	Hodgkins lymphoma	American Scitech International	Unknown	No outcome recorded
Phase 2	NCT00654732 Background	Mar 2008 → Sep 2018	classic Hodgkin lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 2	NCT00352027 Background	Jul 2006 → May 2015	Hodgkins lymphoma	St. Jude Children's Research Hospital	Completed	No outcome recorded
Phase 2	NCT00079105 Comparator	Jan 2004 → Dec 2010	lymphoma	Newcastle-upon-Tyne Hospitals NHS Trust	Completed	No outcome recorded
Phase 2	NCT02161692 Comparator	Dec 1996 → May 2007	germ cell tumor, neoplasm of testis	Fondazione IRCCS Istituto Nazionale dei Tumori, Milano	Completed	Missed primary
Phase 2	NCT01404936 Background	Jul 1996 → Dec 2011	lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 2/3	NCT00003643 Background	Oct 1998 → ?	extragonadal germ cell tumor, teratoma, testicular germ cell tumor	European Organisation for Research and Treatment of Cancer - EORTC	Unknown	No outcome recorded
Phase 3	NCT04685616 Comparator	Apr 2022 → Sep 2030 expected	Hodgkins lymphoma	University College, London	Recruiting	No outcome recorded
Phase 3	NCT03067181 Background	May 2017 → Jun 2027 expected	childhood germ cell tumor, choriocarcinoma of ovary, choriocarcinoma of testis, malignant teratoma +7	Children's Oncology Group	Recruiting	No outcome recorded
Phase 3	NCT02661503 Comparator	Jul 2016 → Dec 2022	classic Hodgkin lymphoma	University of Cologne	Unknown	Met primary
Phase 3	NCT02429700 Comparator	Apr 2015 → May 2025 overdue	ovarian cancer, ovarian sex cord-stromal tumor	Beihua Kong	Recruiting	No outcome recorded
Phase 3	NCT02429687 Comparator	Apr 2015 → May 2025 overdue	malignant germ cell tumor of ovary	Beihua Kong	Recruiting	No outcome recorded
Phase 3	NCT02166463 Comparator	Mar 2015 → Dec 2021 overdue	classic Hodgkin lymphoma	National Cancer Institute (NCI)	Active not recruiting	Met primary
Phase 3	NCT01712490 Comparator	Nov 2012 → Apr 2017	Hodgkins lymphoma	Takeda	Completed	Met primary
Phase 3	NCT01659099 Background	Sep 2012 → Aug 2016	diffuse large B-cell lymphoma	The Lymphoma Academic Research Organisation	Terminated	Missed primary
Phase 3	NCT01356680 Background	Jan 2012 → Mar 2020	Hodgkins lymphoma	University of Cologne	Completed	No outcome recorded
Phase 3	NCT00816959 Comparator	Jul 2011 → Apr 2014	Hodgkins lymphoma	American Scitech International	Unknown	No outcome recorded
Phase 3	NCT01358747 Comparator	May 2011 → ?	Hodgkins lymphoma	Centre Hospitalier Universitaire Dijon	Completed	Met primary
Phase 3	NCT00736320 Background	Nov 2009 → Sep 2018	Hodgkins lymphoma	University of Cologne	Unknown	No outcome recorded
Phase 3	NCT00038558 Background	Nov 2001 → Feb 2004	Hodgkins lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 3	NCT01251107 Comparator	Mar 2000 → Nov 2009	Hodgkins lymphoma	Fondazione Michelangelo	Completed	No outcome recorded
Phase 3	NCT00264953 Background	May 1998 → Jan 2003	Hodgkins lymphoma	University of Cologne	Completed	Mixed
Phase 3	NCT00577993 Comparator	Mar 1998 → Aug 2017	lymphoma	M.D. Anderson Cancer Center	Completed	No outcome recorded
Phase 3	NCT00005578 Background	Mar 1997 → Oct 2004	chemotherapy-induced toxicity, lymphoma	Children's Oncology Group	Completed	No outcome recorded
Phase 3	NCT00002561 Comparator	Jan 1994 → Aug 2011	Hodgkins lymphoma	NCIC Clinical Trials Group	Completed	No outcome recorded
Phase 4	NCT04582305 Comparator	Mar → Nov 2022	keloid	Erasmus Medical Center	Unknown	No outcome recorded
Phase 4	NCT03477448 Comparator	Apr 2018 → Apr 2019	plantar wart	Assiut University	Unknown	No outcome recorded
Phase 4	NCT02526823 Comparator	Aug 2015 → Dec 2019	lymphoma	Shandong Provincial Hospital	Unknown	No outcome recorded
Phase 4	NCT01347294 Comparator	Aug 2011 → Nov 2023	vascular malformation	Oslo University Hospital	Unknown	No outcome recorded
Phase 4	NCT00380770 Comparator	Jan 2003 → Feb 2009	AIDS, Kaposi's sarcoma, human herpesvirus 8 infection	University of KwaZulu	Completed	No outcome recorded
—	NCT07041749 Comparator	Jun 2026 → Jun 2027 expected	plantar wart	Assiut University	Not yet recruiting	No outcome recorded
—	NCT07498959 Comparator	Mar 2026 → Mar 2031 expected	testicular seminoma	Sahlgrenska University Hospital	Recruiting	No outcome recorded
—	NCT05057663 Comparator	Nov 2021 → Mar 2022	plantar wart	Sohag University	Unknown	No outcome recorded
—	NCT00066482 Background	Jul 2004 → Apr 2007	childhood germ cell tumor, extragonadal germ cell tumor	Children's Oncology Group	Completed	No outcome recorded

News releases announcing trial results or a regulatory action · 2

Date	Issuer	Release
2024-06-01	Pfizer	Results Takeda and Pfizer Announce Four-Year Results from Positive Phase 3 HD21 Trial of Additional ADCETRIS® (brentuximab vedotin) Combination in Frontline Hodgkin Lymphoma pfizer.com ↗ The four-year analysis presented by the GHSG showed superior progression-free survival (PFS) and improved tolerability for patients compared to a current standard of care regimen used in Europe in this setting.
2022-05-26	Takeda	Results Takeda and Seagen to Highlight ADCETRIS ® Combination Data Showing Statistically Significant Improvement in Overall Survival (OS) for Patients with Advanced Hodgkin Lymphoma takeda.com ↗ These results clearly show that the addition of brentuximab vedotin to chemotherapy improves the long-term outcome of patients and the combination should be considered a standard of care.

All press releases naming this drug 2 releases

Date	Issuer	Release
2024-06-01	Pfizer	Takeda and Pfizer Announce Four-Year Results from Positive Phase 3 HD21 Trial of Additional ADCETRIS® (brentuximab vedotin) Combination in Frontline Hodgkin Lymphoma pfizer.com ↗
2022-05-26	Takeda	Takeda and Seagen to Highlight ADCETRIS ® Combination Data Showing Statistically Significant Improvement in Overall Survival (OS) for Patients with Advanced Hodgkin Lymphoma takeda.com ↗

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 188 sources stand behind the page.

Field	Value	Cited text
Known as	Bleomycin	“Chemotherapy is based upon regimes with well known effectiveness in Hodgkin lymphoma. (i.e. ABVD: doxorubicin, bleomycin, vinblastine and dacarbazine and ESHAP: Etoposide,...” NCT03500133 ↗ 166 “The other half (Group II) will receive a combination of intravenous Adriamycin, Bleomycin, Vinblastine and Dacarbazine every other week for 12 treatments.” NCT00797472 ↗ “Doxorubicin 25 mg/m2 IV, Bleomycin 10,000 units/m2 IV, Vinblastine 6 mg/m2 IV, Dacarbazine 375 mg/m2 IV on days 1-15 of each 28 day cycle.” NCT02275598 ↗ “BACOPP-D regimen which includes cyclophosphamide, adriamycin, dacarbazine, procarbazine, prednisolone, bleomycin and vincristine” NCT00188149 ↗ “Adriamycin 25 mg/m2 bleomycin 10 units/m2 vinblastine 6 mg/m2 dacarbazine 375 mg/m on Days 1 and 15 of each 28 day cycle” NCT00901303 ↗ “doxorubicin 25 mg/m\^2 IV bleomycin 10 units/m\^2 IV vinblastine 6 mg/m\^2 IV dacarbazine 375 mg/m\^2 IV” NCT01118026 ↗ “BEACOPPescalated consisted of bleomycin 10 mg/m2 and vincristine 1·4 mg/m2 intravenously on day 8” PMID 30658935 ↗ Jan 2019 “doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)-based response-adapted therapy” NCT01652261 ↗ “Bleomycin (B) 5units/m2/day IV over 10min on Day 1 10units/m2/day IV over 10min on Day 8” NCT01858922 ↗ “Adriamycin 25mg/m2, Bleomycin10,000units/m2, Vinblastine 6mg/m2 and Dacarbazine 375mg/m2” NCT03527628 ↗ “vincristine sulfate IV and bleomycin IV on day 1 of weeks 2, 4, 6, and 8” NCT00846742 ↗ Show 156 more sources
Known as	BLEO	“Bleomycin, BLEO, NSC-125066” NCT00002462 ↗ 1 “BLEO Bleomycin, NSC-125066” NCT00002565 ↗
Known as	Bleomicina	ClinicalTrials.gov intervention name — accepted as the source's own label NCT06715592 ↗ 1 NCT01067690 ↗
Known as	Bleomicine	“Esc.BEACOPP Bleomicine10 mg/m2/ev/die 8°” NCT00795613 ↗
Known as	Bleomycin (B)	“Bleomycin (B)” NCT01858922 ↗
Known as	Bleomycin hydrochloride	“Bleomycin hydrochloride injection: 10mg/m2, IV or IM, day 8” NCT02800447 ↗
Known as	Bleomycin PHC 15 e.	“Bleomycin PHC 15 e. (United States Pharmacopeia - USP)” NCT02352259 ↗
Known as	Bleomycin Sulfate	“The MedPulser device will be used in combination with Bleomycin Sulfate injection around the tumor area in a concentration of 1 U/ml per cm3 of tumor treatment area.” NCT00198276 ↗ 29 “Patients receive injections of Bleomycin Sulfate at a concentration of 1 U/ml per cm3 of tumor treatment area followed by electroporation.” NCT00198328 ↗ “Bleomycin sulfate was administered at a dose of 15 units/m\^2 over 10 minutes every 3 weeks.” NCT01435018 ↗ “Bleomycin (active name: Bleomycin Sulfate)” NCT02582697 ↗ “Biological: bleomycin sulfate” NCT00002571 ↗ “Biological: bleomycin sulfate” NCT00678327 ↗ “Biological: bleomycin sulfate” NCT00079105 ↗ “Biological: bleomycin sulfate” NCT00005090 ↗ “Biological: bleomycin sulfate” NCT00002565 ↗ “Biological: Bleomycin sulfate” NCT00002715 ↗ “Biological: bleomycin sulfate” NCT00049595 ↗ Show 19 more sources
Known as	NSC-125066	“Bleomycin, BLEO, NSC-125066” NCT00002462 ↗ 2 “Bleomycin, BLEO, NSC-125066” NCT00002476 ↗ “BLEO Bleomycin, NSC-125066” NCT00002565 ↗
Action	Inhibit	“Drugs used in chemotherapy, such as doxorubicin hydrochloride, bleomycin, vinblastine, and dacarbazine, work in different ways to stop the growth of tumor cells” NCT00654732 ↗
Route	Intravenous	“Four medicines are given on day 1 of each cycle by vein (IV) (doxorubicin, cyclophosphamide, bleomycin, vincristine).” NCT00000689 ↗