drugset / Trial / NCT00577993

Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Rituximab for Lymphoma Patients

NCT00577993

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical research study is to compare chemotherapy given with rituximab to chemotherapy followed by rituximab. The safety of both treatment schedules will be studied. Laboratory tests of genetic changes in blood and bone marrow before and during the study will also be monitored.

Timeline

Start
1998-03-16
Primary completion
2017-08-24
Completion
2017-08-24

Drugs

EvaluationDrugModalityDoseRoute
Comparator Bleomycin Unknown 5 unknown Intravenous
Comparator Cisplatin Other / unclassified 25 mg/m2 Intravenous
Comparator Cyclophosphamide Other / unclassified 750 mg/m2 Intravenous
Comparator Cytarabine Small molecule 1.5 unknown Intravenous
Comparator Dexamethasone Small molecule 20 mg Intravenous
Comparator Dexamethasone Small molecule 40 mg Intravenous
Comparator Doxorubicin Other / unclassified 25 mg/m2 Intravenous
Comparator Etoposide Small molecule 40 mg/m2 Intravenous
Comparator Fludarabine Small molecule 25 mg/m2 Intravenous
Comparator Methylprednisolone Other / unclassified 500 mg Intravenous
Comparator Mitoxantrone Small molecule 10 mg/m2 Intravenous
Comparator Prednisone Other / unclassified 100 mg Oral
Comparator Rituximab Monoclonal antibody 375 mg/m2 Intravenous
Comparator Vincristine Small molecule 0.7 mg/m2 Intravenous
Comparator Vincristine Small molecule 1.4 mg/m2 Intravenous
Comparator interferon alfa-2b Protein / enzyme biologic 3 unknown Subcutaneous
Comparator procarbazine Small molecule 100 mg/m2 Oral

Indications