Drugs / Izalontamab Brengitecan

Trials 52 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 16 trials
Phase 1 NCT07382726 Jul 2026 → Dec 2027 expected non-small cell lung carcinoma M.D. Anderson Cancer Center Not yet recruiting No outcome recorded
Phase 1 NCT05983432 Aug 2023 → Dec 2026 expected cervical cancer, endometrial cancer, esophageal cancer, head and neck squamous cell carcinoma +6 SystImmune Inc. Recruiting No outcome recorded
Phase 1 NCT05470348 Aug 2022 → Dec 2026 expected breast cancer Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1 NCT05393427 Feb 2022 → Dec 2025 overdue malignant urinary system neoplasm Sichuan Baili Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT05262491 Feb 2022 → Dec 2026 expected digestive system neoplasm Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1 NCT05194982 Nov 2021 → Dec 2026 expected Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT07307053 Jan 2026 → Jan 2029 expected high grade malignant neoplasm, metastatic neoplasm Cancer Institute and Hospital, Chinese Academy of Medical Sciences Not yet recruiting No outcome recorded
Phase 1/2 NCT06618287 Feb 2025 → Feb 2031 expected breast cancer, lung cancer Bristol-Myers Squibb Recruiting No outcome recorded
Phase 1/2 NCT05803018 Jun 2023 → Dec 2026 expected female reproductive organ cancer Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 222 trials
Phase 2 NCT07054567 Aug 2025 → May 2027 expected cervical cancer, endometrial cancer Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06962787 Jul 2025 → May 2027 expected kidney cancer Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06951464 Jun 2025 → May 2027 expected non-small cell lung carcinoma Sichuan University Recruiting No outcome recorded
Phase 2 NCT06986785 Jun 2025 → May 2027 expected hepatocellular carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06978114 Jun 2025 → May 2027 expected biliary tract cancer Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06787664 Jan 2025 → Jun 2027 expected chordoma Sichuan Baili Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 2 NCT06598787 Oct 2024 → Oct 2026 expected glioblastoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06471205 Aug 2024 → Jul 2026 overdue triple-negative breast carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06498986 Jul 2024 → Aug 2026 overdue non-small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2 NCT06475300 Jun 2024 → Jul 2026 overdue nasopharyngeal carcinoma, non-small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2/36 trials
Phase 2/3 NCT07554456 Jun 2026 → Dec 2028 expected esophageal squamous cell carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 2/3 NCT07642024 Jun 2026 → Dec 2032 expected non-small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 2/3 NCT07641855 Jun 2026 → Dec 2028 expected castration-resistant prostate carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 2/3 NCT07100080 Nov 2025 → Dec 2028 expected non-small cell lung carcinoma Bristol-Myers Squibb Recruiting No outcome recorded
Phase 2/3 NCT07106762 Sep 2025 → Jan 2029 expected urothelial carcinoma Bristol-Myers Squibb Recruiting No outcome recorded
Phase 2/3 NCT06926868 Sep 2025 → Mar 2028 expected breast neoplasm Bristol-Myers Squibb Recruiting No outcome recorded
Phase 315 trials
Phase 3 NCT07680790 Sep 2026 → Dec 2031 expected non-small cell lung carcinoma Bristol-Myers Squibb Not yet recruiting No outcome recorded
Phase 3 NCT07582315 Jul 2026 → Dec 2028 expected biliary tract cancer Sichuan Baili Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT07648914 Jun 2026 → Dec 2028 expected breast cancer Sichuan Baili Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT07640789 Jun 2026 → Dec 2030 expected non-small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT07502300 Apr 2026 → Dec 2029 expected small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Not yet recruiting No outcome recorded
Phase 3 NCT06994195 Aug 2025 → Jun 2027 expected fallopian tube cancer, malignant epithelial tumor of ovary, primary peritoneal carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT06857175 Mar 2025 → Jun 2027 expected urothelial carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT06838273 Feb 2025 → Dec 2028 expected non-small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Recruiting No outcome recorded
Phase 3 NCT06500026 Aug 2024 → Dec 2026 expected small cell lung carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded
Phase 3 NCT06382142 Jun 2024 → Jun 2026 overdue triple-negative breast carcinoma Sichuan Baili Pharmaceutical Co., Ltd. Active not recruiting No outcome recorded

Press releases naming this drug 1 release

DateIssuerRelease
2026-06-02 Bristol-Myers Squibb Izalontamab Brengitecan (Iza-Bren) Demonstrates Statistically Significant and Clinically Meaningful Improvements in Overall Survival and Progression-Free Survival in Patients with Triple-Negative Breast Cancer and Esophageal Squamous Cell Carcinoma bms.com

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 54 sources stand behind the page.

FieldValueCited text
Known as Izalontamab Brengitecan “This research is being done to test a combination of two drugs, Izalontamab Brengitecan (iza-bren) and Adagrasib, in patients with advanced KRAS G12C-mutant NSCLC that hasn't...” NCT07382726
Known as BL-B01D1 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06962787
45

NCT05393427

NCT07582315

NCT06471205

NCT06787664

NCT06978114

NCT05956587

NCT06006169

NCT06475300

NCT06437509

NCT05880706

NCT06382142

NCT06382129

NCT05262491

NCT06382116

NCT05990803

NCT06304974

NCT05785039

NCT07307053

NCT05983432

NCT06986785

NCT06118333

NCT07554456

NCT07642024

NCT07641855

NCT06437522

NCT06405425

NCT07640789

NCT05803018

NCT05470348

NCT05194982

NCT06500026

NCT05965856

NCT07054567

NCT06951464

NCT06994195

NCT06598787

NCT06857175

NCT06343948

NCT06838273

NCT06008054

NCT07648914

NCT07502300

NCT06498986

NCT06042894

NCT05924841

Known as BMS-986507 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06618287
Known as iza-bren “This research is being done to test a combination of two drugs, Izalontamab Brengitecan (iza-bren) and Adagrasib, in patients with advanced KRAS G12C-mutant NSCLC that hasn't...” NCT07382726
5

NCT07100080

NCT07382726

NCT07680790

NCT06926868

NCT07106762

Route Intravenous “patients received intravenous BL-B01D1” PMID 38823410 May 2024
Target EGFR “targeting EGFR and human epidermal growth factor receptor 3 (HER3)” PMID 41611210 Jan 2026