Drugs / Natural Killer Cells
last change May 2026 re-read 3 minutes ago

Natural Killer Cells

Cell therapy

Developed for
acute myeloid leukemia · non-small cell lung carcinoma · Alzheimer disease · chronic lymphocytic leukemia/small lymphocytic lymphoma · esophageal cancer · head and neck squamous cell carcinoma · metastatic malignant neoplasm · neuroblastoma
+25 more · ovarian cancer · breast cancer · carcinoma · cervical cancer · chronic myeloid leukemia · colorectal cancer · colorectal neoplasm · COVID-19 · digestive system cancer · endometrial cancer · fallopian tube cancer · gastric cancer · HER2 positive breast carcinoma · Hodgkins lymphoma · malignant pancreatic neoplasm · metastatic neoplasm · myelodysplastic syndrome · plasma cell myeloma · primary peritoneal carcinoma · psoriasis · rectal cancer · refractory malignant neoplasm · sarcoma · triple-negative breast carcinoma · urinary bladder cancer
Investigated by
NKGen Biotech, Inc. · Masonic Cancer Center, University of Minnesota · Affimed GmbH · CURE Childhood Cancer, Inc. · Centre Hospitalier Universitaire de Besancon · David Wald
+9 more · First Affiliated Hospital Xi'an Jiaotong University · Hospital de Clinicas de Porto Alegre · Miltenyi Biomedicine GmbH · NKMAX Co., Ltd. · National Cancer Institute, France · National Taiwan University Clinical Trial Center · National Taiwan University Hospital, Yun-Lin Branch · Nationwide Children's Hospital · St. Jude Children's Research Hospital

Trials 20

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT05400122 Sep 2022 → Dec 2026 Hodgkins lymphoma, acute myeloid leukemia, chronic lymphocytic leukemia/small lymphocytic lymphoma, chronic myeloid leukemia +5 David Wald Suspended No outcome recorded
Phase 1 NCT05333705 Jul 2021 → Jul 2024 acute myeloid leukemia First Affiliated Hospital Xi'an Jiaotong University Unknown No outcome recorded
Phase 1 NCT04678453 Jan 2021 → Aug 2023 Alzheimer disease NKGen Biotech, Inc. Terminated No outcome recorded
Phase 1 NCT04634370 Jan → Mar 2021 COVID-19 Hospital de Clinicas de Porto Alegre Unknown No outcome recorded
Phase 1 NCT03894579 Jul → Dec 2019 psoriasis NKGen Biotech, Inc. Completed No outcome recorded
Phase 1 NCT03941262 Jul 2019 → Feb 2023 carcinoma, metastatic malignant neoplasm NKGen Biotech, Inc. Completed No outcome recorded
Phase 1 NCT01576692 Apr 2012 → Oct 2014 neuroblastoma St. Jude Children's Research Hospital Completed No outcome recorded
Phase 1 NCT02845999 Nov 2009 → Jan 2013 digestive system cancer Centre Hospitalier Universitaire de Besancon Completed No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT06189963 Nov 2023 → Dec 2026 expected Alzheimer disease NKGen Biotech, Inc. Recruiting No outcome recorded
Phase 1/2 NCT04211675 Sep 2022 → Dec 2026 expected neuroblastoma Nationwide Children's Hospital Recruiting No outcome recorded
Phase 1/2 NCT05099549 Nov 2021 → Sep 2023 colorectal neoplasm, head and neck squamous cell carcinoma, metastatic neoplasm, non-small cell lung carcinoma +1 NKGen Biotech, Inc. Terminated No outcome recorded
Phase 1/2 NCT04872634 Jul 2021 → May 2023 non-small cell lung carcinoma NKMAX Co., Ltd. Unknown No outcome recorded
Phase 1/2 NCT04464967 Mar 2021 → Aug 2022 HER2 positive breast carcinoma, cervical cancer, colorectal cancer, endometrial cancer +9 NKGen Biotech, Inc. Withdrawn No outcome recorded
Phase 1/2 NCT00303667 Jan 2005 → Mar 2011 acute myeloid leukemia Masonic Cancer Center, University of Minnesota Completed No outcome recorded
Phase 26 trials
Phase 2 NCT07228078 Jun 2025 → Apr 2028 expected Alzheimer disease NKGen Biotech, Inc. Recruiting No outcome recorded
Phase 2 NCT07202611 Dec 2022 → Sep 2025 overdue non-small cell lung carcinoma National Taiwan University Clinical Trial Center Recruiting No outcome recorded
Phase 2 NCT01639456 Oct 2013 → Jan 2017 acute myeloid leukemia Masonic Cancer Center, University of Minnesota Withdrawn No outcome recorded
Phase 2 NCT01181258 Aug 2010 → Sep 2015 chronic lymphocytic leukemia/small lymphocytic lymphoma Masonic Cancer Center, University of Minnesota Completed No outcome recorded
Phase 2 NCT01106950 Jul 2010 → Oct 2011 acute myeloid leukemia Masonic Cancer Center, University of Minnesota Terminated No outcome recorded
Phase 2 NCT01105650 Jul 2010 → Apr 2014 breast cancer, fallopian tube cancer, ovarian cancer, primary peritoneal carcinoma Masonic Cancer Center, University of Minnesota Completed No outcome recorded
Comparator or background therapy3 trials
Phase 1 NCT07443020 Background May 2026 → Mar 2033 expected malignant mesothelioma, pleural neoplasm Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Recruiting No outcome recorded
Phase 1 NCT06190249 Background Dec 2024 → Jan 2028 melanoma James Isaacs, MD Withdrawn No outcome recorded Stop: Enrollment
Phase 2 NCT00059475 Background Apr 2003 → May 2010 melanoma National Cancer Institute (NCI) Completed No outcome recorded

Press releases naming this drug 39 releases

DateIssuerRelease
2025-08-06 NKGen Biotech, Inc. NKGen Biotech To Present on Allogeneic Enhanced NK Cells without Lymphodepletion in Solid Tumors at the 13th Annual Immuno-Oncology Summit nkgenbiotech.com ↗
2024-07-30 NKGen Biotech, Inc. NKGen Biotech Presents New Positive SNK01 Biomarker Data at the 2024 Alzheimer’s Association International Conference nkgenbiotech.com ↗
2024-07-18 NKGen Biotech, Inc. NKGen Biotech to Present New Positive SNK01 Clinical Trial Biomarker Data at the 2024 Alzheimer’s Association International Conference nkgenbiotech.com ↗
2024-05-20 NKGen Biotech, Inc. NKGen Biotech’s SNK01 NK Cell Therapy Cleared to Start Phase 2 Clinical Trial in Alzheimer’s Disease nkgenbiotech.com ↗
2024-04-29 NKGen Biotech, Inc. NKGen Biotech Announces FDA Clearance of Investigational New Drug (IND) Application for SNK01 NK Cell Therapy in Parkinson’s Disease nkgenbiotech.com ↗
2024-04-18 NKGen Biotech, Inc. NKGen Biotech Announces Upcoming Presentation on SNK01 NK Cell Therapy in Neurodegenerative Disease at the 12th Annual Alzheimer’s & Parkinson’s Drug Development Summit nkgenbiotech.com ↗
2024-04-08 Celularity Incorporated Celularity to Present Data Showing Senescent Cell Elimination by Off-the-Shelf Natural Killer Cells Derived from Human Placental Cells celularity.com ↗
2024-03-04 NKGen Biotech, Inc. NKGen Biotech Announces Upcoming Presentation on SNK01 in Alzheimer’s Disease at the Tau2024 Global Conference nkgenbiotech.com ↗
2023-12-28 NKGen Biotech, Inc. NKGen Biotech, Inc. Announces Dosing of First Patient in its Phase 1/2a Trial with Autologous NK Cell Product, SNK01, for the Treatment of Moderate Alzheimer’s Disease nkgenbiotech.com ↗
2023-12-27 NKGen Biotech, Inc. NKGen Biotech Announces Clearance of Clinical Trial Application by Health Canada for SNK01 NK Cell Therapy to Treat Alzheimer’s Disease nkgenbiotech.com ↗
2023-10-24 NKGen Biotech, Inc. NKGen Biotech Announces FDA Clearance of Investigational New Drug Application for SNK01 NK Cell Therapy to Treat Alzheimer’s Disease nkgenbiotech.com ↗
2023-06-05 NKGen Biotech, Inc. NKGen Biotech Announces SNK01 Preclinical and Phase I/IIa Clinical Data Presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting nkgenbiotech.com ↗

Evidence & citations 10 cited values

Every value below carries the sentence it was read from. 23 sources stand behind the page.

FieldValueCited text
Known as natural killer cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT07202611 ↗
10

NCT01106950 ↗

NCT04211675 ↗

NCT05400122 ↗

NCT02845999 ↗

NCT05333705 ↗

NCT01576692 ↗

NCT04634370 ↗

NCT00303667 ↗

NCT01105650 ↗

NCT01181258 ↗

Known as Allogenic NK cells “Allogenic NK cells will then be adoptively transferred by hepatic intraarterial infusion according to a dose escalation protocol” NCT02845999 ↗
Known as CD3-CD56+ natural killer cells ClinicalTrials.gov intervention name — accepted as the source's own label NCT01639456 ↗
Known as Interleukin-2 (IL-2) ClinicalTrials.gov intervention name — accepted as the source's own label NCT07443020 ↗
2

NCT06190249 ↗

NCT00059475 ↗

Known as NK cells “Haploidentical Natural Killer (NK) cells can persist and expand in vivo following adoptive transfer” NCT02845999 ↗
Known as SNK01 ClinicalTrials.gov intervention name — accepted as the source's own label NCT06189963 ↗
7

NCT03894579 ↗

NCT03941262 ↗

NCT04872634 ↗

NCT04678453 ↗

NCT07228078 ↗

NCT05099549 ↗

NCT04464967 ↗

Known as Super Natural Killer Cells 01 “SNK01 (Super Natural Killer Cells 01)” NCT04872634 ↗
Action Deplete “can trigger NK cell elimination of that target cell” NCT02845999 ↗
Modality Cell therapy “allogeneic natural killer (NK) cells” NCT01105650 ↗
Route Intravenous “interleukin-2 (IL-2) is given intravenously (through a small tube placed in a vein)” NCT00059475 ↗